Evidence map›Paper›PMID 35437147›Full record

ArticleFertility and sterility2022

Coronavirus disease 2019 vaccination and infertility treatment outcomes.

Sarit Avraham, Alon Kedem, Hilli Zur, Michal Youngster, Odelia Yaakov, Gil M Yerushalmi, Itai Gat, Yariv Gidoni, Alyssa Hochberg, Micha Baum and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Fertility and sterility, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 6 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 6 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Effect of COVID-19 vaccination on the outcome ofFrontiers in public health · 2023
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Impact of COVID-19 Vaccination on Female Fertility.Reproductive sciences (Thousand Oaks, Calif.) · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Female reproduction and abnormal uterine bleeding after COVID-19 vaccination.Clinical and experimental reproductive medicine · 2023
    Article
  17. SARS-CoV-2, fertility and assisted reproduction.Human reproduction update · 2023
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Sarit AvrahamIVF Unit, Department of Obstetrics and Gynecology, Shamir Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel. Electronic address: sritav@gmail.com.
Alon KedemIVF Unit, Department of Obstetrics and Gynecology, Shamir Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel.
Hilli ZurIVF Unit, Department of Obstetrics and Gynecology, Shamir Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel.
Michal YoungsterIVF Unit, Department of Obstetrics and Gynecology, Shamir Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel.
Odelia YaakovIVF Unit, Department of Obstetrics and Gynecology, Shamir Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel.
Gil M YerushalmiIVF Unit, Department of Obstetrics and Gynecology, Shamir Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel.
Itai GatIVF Unit, Department of Obstetrics and Gynecology, Shamir Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel.
Yariv GidoniIVF Unit, Department of Obstetrics and Gynecology, Shamir Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel.
Alyssa HochbergIVF Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel.
Micha BaumIVF Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel, and IVF Unit, Herzliya Medical Center, Herzliya, Israel.
Ariel HourvitzIVF Unit, Department of Obstetrics and Gynecology, Shamir Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel.
Ettie MamanIVF Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel, and IVF Unit, Herzliya Medical Center, Herzliya, Israel.
Tel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the influence of coronavirus disease 2019 (COVID-19) messenger ribonucleic acid vaccine on ovarian response and in vitro fertilization (IVF) treatment outcomes.

designA retrospective cohort study.

settingA tertiary university-affiliated medical center and a private medical center. PATIENT(S): The study included a total of 400 patients, 200 vaccinated women and 200 age-matched unvaccinated women, who underwent IVF in January-April 2021. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The mean number of oocytes retrieved and clinical pregnancy rates in vaccinated vs. unvaccinated patients. RESULT(S): A total of 200 patients underwent oocyte retrieval 14-68 days after receiving COVID-19 vaccination. No difference was found in the mean number of oocytes retrieved per cycle (10.63 vs. 10.72) between vaccinated and unvaccinated patients. Among 128 vaccinated and 133 unvaccinated patients who underwent fresh embryos transfers, no difference was demonstrated in the clinical pregnancy rates (32.8% vs. 33.1%), with 42 and 44 clinical pregnancies, respectively. The fertilization rates and mean number of cryopreserved embryos were similar between the 2 groups in freeze-all cycles (55.43% vs. 54.29% and 3.59 vs. 3.28, respectively). Among vaccinated and unvaccinated patients who underwent fresh embryo transfers, no difference was noted in the fertilization rate (64.81% vs. 61.98%) and transferred embryos' quality. Regression models applied demonstrated no effect of the vaccine on oocyte yields and pregnancy rates. CONCLUSION(S): The COVID-19 messenger ribonucleic acid vaccine did not affect the ovarian response or pregnancy rates in IVF treatment. Women should be vaccinated for COVID-19 before attempting to conceive via IVF treatments, given the higher risk of severe illness in pregnant women.

Indexed as

COVID-19COVID-19 VaccinesFertilization in VitroInfertilityFemaleHumansOocyte RetrievalOvulation InductionPregnancyPregnancy RateRetrospective StudiesTreatment OutcomeVaccinationCOVID-19 VaccinesCOVID-19infertility treatmentsmRNA vaccine

Identifiers

PMID35437147
PMCPMC8872833
OpenAlexW4214499001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.