Evidence map›Paper›PMID 35437016›Full record

ArticleJournal of the American Chemical Society2022

Copper-Mediated Radiocyanation of Unprotected Amino Acids and Peptides.

Liam S Sharninghausen, Sean Preshlock, Stephen T Joy, Mami Horikawa, Xia Shao, Wade P Winton, Jenelle Stauff, Tanpreet Kaur, Robert A Koeppe, Anna K Mapp and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Recent advances in [Nuclear medicine and biology · 2026
    Review
  2. Article
  3. Review
  4. Automated production ofJournal of labelled compounds & radiopharmaceuticals · 2024
    Article
  5. Photo- and Cu-MediatedOrganic letters · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Strategies for the Production of [Organic process research & development · 2023
    Article
  10. Diagnostic and Therapeutic Radiopharmaceuticals.ACS pharmacology & translational science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Liam S SharninghausenDepartment of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-2249-1010
Sean PreshlockDepartment of Radiology, University of Michigan, 1301 Catherine, Ann Arbor, Michigan 48109, United States.
Stephen T JoyDepartment of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States.
Mami HorikawaDepartment of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-6317-0689
Xia ShaoDepartment of Radiology, University of Michigan, 1301 Catherine, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-7291-2477
Wade P WintonDepartment of Radiology, University of Michigan, 1301 Catherine, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-4986-0170
Jenelle StauffDepartment of Radiology, University of Michigan, 1301 Catherine, Ann Arbor, Michigan 48109, United States.
Tanpreet KaurDepartment of Radiology, University of Michigan, 1301 Catherine, Ann Arbor, Michigan 48109, United States.
Robert A KoeppeDepartment of Radiology, University of Michigan, 1301 Catherine, Ann Arbor, Michigan 48109, United States.
Anna K MappDepartment of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States.ORCID 0000-0003-0791-8327
Peter J H ScottDepartment of Radiology, University of Michigan, 1301 Catherine, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-6505-0450
Melanie S SanfordDepartment of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-9342-9436
University of Michigan · US

Funding

Probing transcriptional activation at the molecular level - Equipment SupplementR35GM136356 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANNA K. MAPP · 2020 to 2026
$3.3M
Synthesis of Novel PET Radiotracers for Imaging in Alzheimer’s Disease and Related DisordersR01EB021155 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANFORD, MELANIE S., SCOTT, PETER JAMES HENRY · 2016 to 2024
$3.2M
Copper Catalyzed Fluorination of Aryl HalidesF32GM136022 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHARNINGHAUSEN, LIAM SHIN · 2020 to 2021
$131k
NIBIB NIH HHS R01 EB021155NIGMS NIH HHS F32 GM136022NIGMS NIH HHS R35 GM136356
6 · The paper itself

Abstract

This report describes a copper-mediated radiocyanation of aryl halides that is applicable to complex molecules. This transformation tolerates an exceptionally wide range of functional groups, including unprotected amino acids. As such, it enables the site-specific introduction of [

Indexed as

Amino AcidsCopperAminesAnimalsPositron-Emission TomographyRadiopharmaceuticalsTissue DistributionAminesAmino AcidsCopperRadiopharmaceuticals

Identifiers

PMID35437016
PMCPMC9887455
OpenAlexW4224210066

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.