SynthesisWorld journal of surgical oncology2022
Leiomyosarcoma in the extremities and trunk wall: systematic review and meta-analysis of the oncological outcomes.
Synthesis in World journal of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Primary leiomyosarcoma of the axilla in a 70-year-old female: a case report of multidisciplinary management from a resource-limited setting.Annals of medicine and surgery (2012) · 2026Article
- Vascular Leiomyosarcoma Masquerading as Chronic Deep Venous Thrombosis.Clinical nuclear medicine · 2026Article
- Case Report: Primary sciatic leiomyosarcoma in a patient with neurofibromatosis type 1.Frontiers in oncology · 2026Article
- CT-based quantification of intratumoral heterogeneity for predicting distant metastasis in retroperitoneal sarcoma.Insights into imaging · 2025Article
- Integrated single-cell and bulk RNA-seq analysis reveals prognostic stemness genes in leiomyosarcoma.Frontiers in oncology · 2025Article
- Leiomyosarcoma of lower urinary tract: Literature review.Central European journal of urology · 2025Review
- Primary leiomyosarcoma of the scalp: a case report and review of the literature.Frontiers in oncology · 2025Article
- Urinary incontinence as the first clinical symptom of urinary bladder leiomyosarcoma.Central European journal of urology · 2025Article
- Histology-Tailored Approach to Soft Tissue Sarcoma.Annals of surgical oncology · 2024Review
- Outcomes and Follow-Up Trends in Adrenal Leiomyosarcoma: A Comprehensive Literature Review and Case Report.Journal of clinical medicine · 2024Review
- Deep learning radiomics-based prediction model of metachronous distant metastasis following curative resection for retroperitoneal leiomyosarcoma: a bicentric study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Article
- Establishment and characterization of NCC-LMS3-C1: a novel patient-derived cell line of leiomyosarcoma.Human cell · 2024Article
- Interdisciplinary Surgical Therapy of Extremity Soft-Tissue Sarcomas: A Personalized Resection and Reconstruction Algorithm.Journal of personalized medicine · 2023Article
- Two simple-to-use web-based nomograms to predict overall survival and cancer-specific survival in patients with extremity fibrosarcoma.Frontiers in oncology · 2022Article
- Primary Pulmonary Leiomyosarcoma Managed With Pazopanib: A Case Report and Literature Review.Therapeutic advances in pulmonary and critical care medicineArticle
- Leiomyosarcoma of the Bone: A Case Report on the Critical Role of Biomarkers in Differential Diagnosis.Sage open pathologyArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeiomyosarcomas are aggressive malignancies which can occur on the trunk and extremities whose pathogenesis is poorly understood. We aim to quantify the prognostic impact of various clinical and pathological markers on survival and recurrence of leiomyosarcomas.
methodsWe conducted a systematic review as per PRISMA protocol. Survival, local recurrence, and metastasis were the outcome measures. Data were extracted from the studies for the outcome variables; the resultant odds ratios (OR) and 95% confidence interval (CI) were used for the synthesis of a forest plot.
resultsOur search revealed thirteen studies comprising 1380 patients. Seven of these 13 publications were since 2012. Our analysis showed that tumor size larger than 5 cm adversely affected the outcome with an OR 3.39 (2.26-5.10, p < 0.01). Other factors which reduced the overall survival were positive margins of excision OR 2.12 (1.36-3.32, p < 0.01). A reduced risk of metastasis has strongly associated the use of radiotherapy with OR 10.84 (4.41-26.61, p < 0.01). Only a few studies analyzed the impact of factors on local recurrence.
conclusionsSize larger than 5 cm and positive margins of excision are associated with poor overall survival. In comparison, the use of adjuvant radiotherapy was associated with a lower metastatic rate. There is a need for methodically high-quality studies with more uniform study design and reporting to evaluate the impact of various risk factors on local recurrence and metastases. LEVEL OF EVIDENCE: Level 1 Prognostic.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.