Evidence map›Paper›PMID 35436712›Full record

ArticleOral oncology2022

Impact of AJCC 8th edition staging system and definitive treatment choice on the prognosis of complete responders with p16+ and p16- oropharyngeal squamous cell carcinomas.

R Grant Muller, Chelsea S Hamill, Brandon Vu, Jason Thuener, Jay Wasman, Shawn Li, Nicole Fowler, Rod Rezaee, Pierre Lavertu, Min Yao and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Attributes of HPV associated cancers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

R Grant MullerDepartment of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States.
Chelsea S HamillDepartment of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States.
Brandon VuUniversity Hospitals Seidman Cancer Center, Cleveland, OH 44106, United States.
Jason ThuenerDepartment of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, United States.
Jay WasmanUniversity Hospitals Seidman Cancer Center, Cleveland, OH 44106, United States; Department of Pathology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States.
Shawn LiDepartment of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, United States.
Nicole FowlerDepartment of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, United States.
Rod RezaeeDepartment of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, United States.
Pierre LavertuDepartment of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, United States.
Min YaoUniversity Hospitals Seidman Cancer Center, Cleveland, OH 44106, United States; Department of Radiation Oncology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States.
Kyunghee BurkittUniversity Hospitals Seidman Cancer Center, Cleveland, OH 44106, United States; Department of Medicine, Division of Hematology and Oncology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States.
Jennifer DorthUniversity Hospitals Seidman Cancer Center, Cleveland, OH 44106, United States; Department of Radiation Oncology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States.
Theodoros N TeknosDepartment of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, United States; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States.
Quintin PanDepartment of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, United States; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States. Electronic address: Quintin.Pan@UHhospitals.org.
W Quinn O'NeillDepartment of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, United States. Electronic address: wqo@case.edu.
University Hospitals of Cleveland · USUniversity Hospitals Seidman Cancer Center · US

Funding

Role of P300 in HPV-positive Head and Neck CancerR01DE023555 · NIDCR · OHIO STATE UNIVERSITY · PI ARORA, PARAMJIT S, PAN, QUINTIN · 2015 to 2019
$2.5M
Cancer Initiating Cells and Treatment ResistanceR01CA193590 · NCI · OHIO STATE UNIVERSITY · PI PAN, QUINTIN · 2015 to 2020
$1.8M
NCI NIH HHS R01 CA193590NIDCR NIH HHS R01 DE023555
6 · The paper itself

Abstract

objectivesTo identify predictors of overall survival (OS) in oropharyngeal squamous cell carcinoma (OPSCC) patients who achieved complete response (CR).

methodsWe performed a retrospective study of OPSCC patients who achieved CR from a single academic medical center. Associations between OS, AJCC 8th edition staging system, definitive treatment choice, smoking history, and p16 status were assessed.

resultsp16+ status was associated with favorable prognosis for CR (p < 0.001) but not non-CR (p = 0.67) patients. For early stage, p16+ OPSCC patients who achieved CR, surgery + adjuvant radiation (RT) treatment was more durable compared to concurrent chemoradiation (CRT), particularly in smokers.

conclusionsCurative intent treatment choice and smoking history has an impact on the long-term OS of the CR p16+ OPSCC cohort. Prospective studies to define the optimal multi-modality treatment option to manage p16+ OPSCC patients is needed.

Indexed as

Head and Neck NeoplasmsOropharyngeal NeoplasmsPapillomavirus InfectionsHumansNeoplasm StagingPrognosisProspective StudiesRetrospective StudiesSquamous Cell Carcinoma of Head and NeckAJCC stagingcomplete responsehead and neck cancerhuman papillomavirusoropharyngeal squamous cell carcinomap16

Identifiers

PMID35436712
PMCPMC9624219
OpenAlexW4224011759

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.