Evidence map›Paper›PMID 35436418›Full record

ReviewAnnual review of nutrition2022

Long Noncoding RNAs That Function in Nutrition: Lnc-ing Nutritional Cues to Metabolic Pathways.

Claudia D Lovell, Montserrat C Anguera

Abstract readReview
In one paragraph

Review in Annual review of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. The human-specific noncoding RNAFASEB bioAdvances · 2025
    Article
  5. Review
  6. Long Noncoding RNAs in Diet-Induced Metabolic Diseases.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Claudia D LovellDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; email: anguera@vet.upenn.edu.
Montserrat C AngueraDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; email: anguera@vet.upenn.edu.
University of Pennsylvania · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007170 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BRASS, LAWRENCE F · 1985 to 2022
$54.0M
Gene regulation mechanisms involving the inactive X in B cells during lupus diseaseR01AI134834 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Montserrat C Anguera · 2018 to 2026
$4.2M
Expression of X-linked autoimmunity genes in B cells during female-biased autoimmunityR21AI124084 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ANGUERA, MONTSERRAT C · 2017 to 2018
$443k
NIAID NIH HHS R01 AI134834NIAID NIH HHS R21 AI124084NIGMS NIH HHS T32 GM007170
6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) are sensitive to changing environments and play key roles in health and disease. Emerging evidence indicates that lncRNAs regulate gene expression to shape metabolic processes in response to changing nutritional cues. Here we review various lncRNAs sensitive to fasting, feeding, and high-fat diet in key metabolic tissues (liver, adipose, and muscle), highlighting regulatory mechanisms that trigger expression changes of lncRNAs themselves, and how these lncRNAs regulate gene expression of key metabolic genes in specific cell types or across tissues. Determining how lncRNAs respond to changes in nutrition is critical for our understanding of the complex downstream cascades following dietary changes and can shape how we treat metabolic disease. Furthermore, investigating sex biases that might influence lncRNA-regulated responses will likely reveal contributions toward the observed disparities between the sexes in metabolic diseases.

Indexed as

RNA, Long NoncodingCuesFastingHumansMetabolic Networks and PathwaysRNA, Long Noncodingdiurnal fasting and refeedinghigh-fat dietlong noncoding RNAsmetabolic tissuessex bias in nutritionX-chromosome inactivationXIST RNA

Identifiers

PMID35436418
PMCPMC13432995
OpenAlexW4224210661

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.