ArticleMagnetic resonance in medicine2022
Impact of intra-axonal kurtosis on fiber orientation density functions estimated with fiber ball imaging.
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 3 citations in OpenAlex.
- Interplay of Neuroinflammation and Gut Microbiota Dysbiosis in Alzheimer's Disease Using Diffusion Kurtosis Imaging Biomarker in 3 × Tg-AD Mouse Models.ACS chemical neuroscience · 2025Article
- Intra-voxel angular dispersion of fibers in corpus callosum decreases with healthy aging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The effects of axonal beading and undulation on axonal diameter estimation from diffusion MRI: Insights from simulations in human axons segmented from three-dimensional electron microscopy.NMR in biomedicine · 2024Article
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Abstract
purposeTo determine the impact of an intra-axonal kurtosis on estimates of the fiber orientation density function (fODF) obtained with fiber ball imaging (FBI). THEORY AND
methodsStandard FBI assumes Gaussian diffusion within individual axons and estimates the fODF by applying an inverse generalized Funk transform to diffusion MRI data for b-values of 4000 s/mm
resultsThe first order approximation indicates the estimated fODF is altered by a few percent for an intra-axonal kurtosis of 0.4 in comparison to predictions of standard FBI. If one neglects the intra-axonal kurtosis, the angular resolution of the point spread function for the fODF is changed by <1°, whereas the axonal water fraction is overestimated by ∼ 5%. The gamma distribution model shows that the first order approximation is accurate to within a few percent.
conclusionThe intra-axonal kurtosis has a small impact on fODFs estimated with FBI.
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