ArticlePloS one2022
Association between paracetamol use during pregnancy and perinatal outcomes: Prospective NISAMI cohort.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology.Environmental health : a global access science source · 2025Pooled it
- Prenatal over-the-counter acetaminophen use and birth outcomes in the ECHO Cohort.American journal of epidemiology · 2026Article
- Acetaminophen and pregnancy: common exposure, potential placental impact.Journal of animal science · 2026Review
- Paracetamol exposure during pregnancy, the risk of major congenital malformations, and perinatal and postnatal outcomes: a population-based cohort study.Human reproduction open · 2026Article
- The interaction between paracetamol and ethanol during the early development of zebrafish.Frontiers in pharmacology · 2026Article
- Laparoscopic Cholecystectomy Under Combined Spinal and Epidural Anesthesia in the First Trimester of Pregnancy-Case Report and Literature Review.Life (Basel, Switzerland) · 2024Article
- Understanding Miscarriage Prevalence and Risk Factors: Insights from Women in Jordan.Medicina (Kaunas, Lithuania) · 2024Article
- The Role of the Combination Paracetamol/Caffeine in Treatment of Acute Migraine Pain: A Narrative Review.Pain and therapy · 2024Review
- Association of acetaminophen use with perinatal outcomes among pregnant women: a retrospective cohort study with propensity score matching.BMC pregnancy and childbirth · 2024Article
- Effects of paracetamol/acetaminophen on the expression of solute carriers (SLCs) in late-gestation fetal rat brain, choroid plexus and the placenta.Experimental physiology · 2024Article
- Racial Disparities in Medication Use During Pregnancy: Results from the NISAMI Cohort.Journal of multidisciplinary healthcare · 2024Article
- Neonatal and maternal adverse outcomes and exposure to nonsteroidal anti-inflammatory drugs during early pregnancy in South Korea: A nationwide cohort study.PLoS medicine · 2023Article
- The relationship of prenatal acetaminophen exposure and attention-related behavior in early childhood.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParacetamol is widely used to manage fever and pain during pregnancy worldwide. However, paracetamol may affect the pregnant woman and fetus, once this drug crosses the placental barrier after therapeutic doses and may impair fetal liver function, affecting fetus growth and development. Thus, this study aimed to investigate the association between paracetamol use during pregnancy and perinatal outcomes as preterm birth, low birth weight, and small for gestational age. METHODS AND
findingsData from 760 pregnant women within the NISAMI Cohort between June 2012 and February 2014 were analyzed. Logistic regression was used to estimate the association among paracetamol use during pregnancy and preterm birth, low birth weight, and small for gestational age. Multivariate analyses were adjusted for socioeconomic, maternal, pregnancy, and newborn covariates. Around 14% of women were exposed to paracetamol during pregnancy. A decrease in paracetamol use throughout pregnancy was observed. Lower risk of low birth weight in infants born to women exposed to the drug (OR 0.21; IC 95% 0.01-0.99) was found. Paracetamol use during pregnancy was not statistically associated with preterm birth or small for gestational age.
conclusionsThe findings of this study do not suggest an increased risk of perinatal outcomes. However, it should not be assumed that paracetamol is a risk-free medication and its use must be rational.
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