Evidence map›Paper›PMID 35436013›Full record

ArticleInternational journal of experimental pathology2022

Correlations between histological characterizations and methylation statuses of tumour suppressor genes in Wilms' tumours.

Yen-Chein Lai, Meng-Yao Lu, Wen-Chung Wang, Tai-Cheng Hou, Chen-Yun Kuo

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In one paragraph

Article in International journal of experimental pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yen-Chein LaiDepartment of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.ORCID 0000-0001-9072-5272
Meng-Yao LuDepartment of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Wen-Chung WangDepartment of Obstetrics and Gynecology, Jen-Ai Hospital, Taichung, Taiwan.
Tai-Cheng HouDepartment of Pathology, Jen-Ai Hospital, Taichung, Taiwan.
Chen-Yun KuoDepartment of Pathology, Jen-Ai Hospital, Taichung, Taiwan.
Jen-Ai Hospital · TWChung Shan Medical University Hospital · TWNational Taiwan University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wilms' tumour is a solid tumour that frequently occurs in children. Genetic changes in WT1 and epigenetic aberrations that affect imprinted control region 1 in WT2 loci are implicated in its aetiology. Moreover, tumour suppressor genes are frequently silenced by methylation in this tumour. In the present study, we analysed the methylation statuses of promoter regions of 24 tumour suppressor genes using a methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA)-based approach in 6 Wilms' tumours. Methylation of RASSF1 was specific to all 6 Wilms' tumours and was not observed in normal tissues. Moreover, methylated HIC1 was identified in stromal-type Wilms' tumours and methylated BRCA1 was identified in epithelial-type Wilms' tumours. Unmethylated CASP8, RARB, MLH1_167, APC and CDKN2A were found only in blastemal predominant-type Wilms' tumour. Our results indicated that methylation of RASSF1 may be a vital event in the tumorigenesis of Wilms' tumour, which informs its clinical and therapeutic management. In addition, mixed-type Wilms' tumours may be classified according to epithelial, stromal and blastemal components via MS-MLPA-based approach.

Indexed as

DNA MethylationKidney NeoplasmsWilms TumorChildGenes, Tumor SuppressorHumansPromoter Regions, GeneticTumor Suppressor ProteinsRASSF1 protein, humanTumor Suppressor Proteinsmethylation detectionmolecular pathologymultiplex ligation-dependent probe amplificationnephroblastomatumour suppressor geneWilms' tumour

Identifiers

PMID35436013
PMCPMC9107610
OpenAlexW4224095711

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.