ArticleCurrent topics in behavioral neurosciences2022
Probabilistic Reinforcement Learning and Anhedonia.
Article in Current topics in behavioral neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06044090 (Neuroinflammatory Mechanisms Linking Chronic Stress to Motivational Deficits), which is not on this map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuroinflammatory Mechanisms Linking Chronic Stress to Motivational Deficits
Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- Inflammation-induced depressed mood and reward responsivity as a function of age in female adults: a randomized controlled trial of endotoxin.Translational psychiatry · 2025Trial
- Nociceptin orphanin F/Q Pathways are dysregulated by stress and modulate reward responsiveness and motivated behavior across species.Molecular psychiatry · 2026Article
- Neural response to reward uncertainty in adolescents with mood and anxiety symptoms.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Probing biomarkers and clinical utility of reward learning across species using the Probabilistic Reward Task: 20 years of findings.Nature. Mental health · 2026Article
- Longitudinal analysis of decision-making deficits in binge-eating disorders using drift diffusion modeling.Appetite · 2026Article
- ENX-104: a selective and potent DNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Causal Evidence for Prefrontal-Motor Coupling in Reward-Responsive Goal-Directed Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Reverse Translation.Perspectives on behavior science · 2026Article
- Metabolism and the Mind: Investigating the Link Between Glucose Control and Reinforcement Learning in Humans.Biological psychiatry global open science · 2026Article
- From Neural Circuits to Behavior: Examining the Central Role of Anhedonia in Major Depression.Advances in experimental medicine and biology · 2026Review
- The development of translational tasks for preclinical psychedelic research in psychiatry.Journal of psychopharmacology (Oxford, England) · 2026Review
- Anhedonia is associated with computational impairments in reward and effort learning in young people with depression symptoms.Psychological medicine · 2025Article
- Higher motivation and pleasure scores predict more reliance on model-free decision making.Cognitive, affective & behavioral neuroscience · 2025Article
- Neuroimaging and neuroelectrophysiological features of music's effects on anhedonia in major depressive disorder: A minireview.World journal of psychiatry · 2025Review
- Anhedonia as a Core Symptom of Depression and a Construct for Biological Research.Focus (American Psychiatric Publishing) · 2025Article
- Reinforcement Learning and Decision Making in Depression in Adolescents and Young Adults: Insights from a New Model of the Probabilistic Reward Task.Computational psychiatry (Cambridge, Mass.) · 2025Article
- Electrical brain activations in preadolescents during a probabilistic reward-learning task reflect cognitive processes and behavior strategies.Frontiers in human neuroscience · 2025Article
- Validation of a touchscreen probabilistic reward task for mice: A reverse-translated assay with cross-species continuity.Cognitive, affective & behavioral neuroscience · 2024Article
- Neural Circuitry-Related Biomarkers for Drug Development in Psychiatry: An Industry Perspective.Advances in neurobiology · 2024Review
- Electrophysiological signatures of reward learning in the rodent touchscreen-based Probabilistic Reward Task.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
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Authors and funding
3 authors at 3 institutions in 1 country.
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Abstract
Despite the prominence of anhedonic symptoms associated with diverse neuropsychiatric conditions, there are currently no approved therapeutics designed to attenuate the loss of responsivity to previously rewarding stimuli. However, the search for improved treatment options for anhedonia has been reinvigorated by a recent reconceptualization of the very construct of anhedonia, including within the Research Domain Criteria (RDoC) initiative. This chapter will focus on the RDoC Positive Valence Systems construct of reward learning generally and sub-construct of probabilistic reinforcement learning specifically. The general framework emphasizes objective measurement of a subject's responsivity to reward via reinforcement learning under asymmetrical probabilistic contingencies as a means to quantify reward learning. Indeed, blunted reward responsiveness and reward learning are central features of anhedonia and have been repeatedly described in major depression. Moreover, these probabilistic reinforcement techniques can also reveal neurobiological mechanisms to aid development of innovative treatment approaches. In this chapter, we describe how investigating reward learning can improve our understanding of anhedonia via the four RDoC-recommended tasks that have been used to probe sensitivity to probabilistic reinforcement contingencies and how such task performance is disrupted in various neuropsychiatric conditions. We also illustrate how reverse translational approaches of probabilistic reinforcement assays in laboratory animals can inform understanding of pharmacological and physiological mechanisms. Next, we briefly summarize the neurobiology of probabilistic reinforcement learning, with a focus on the prefrontal cortex, anterior cingulate cortex, striatum, and amygdala. Finally, we discuss treatment implications and future directions in this burgeoning area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.