Evidence map›Paper›PMID 35435497›Full record

Trial reportEuropean journal of nuclear medicine and molecular imaging2022

FDG-PET/CT in indeterminate thyroid nodules: cost-utility analysis alongside a randomised controlled trial.

Elizabeth J de Koster, Dennis Vriens, Maarten O van Aken, Lioe-Ting Dijkhorst-Oei, Wim J G Oyen, Robin P Peeters, Abbey Schepers, Lioe-Fee de Geus-Oei, Wilbert B van den Hout, EfFECTS trial study group

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02208544 (Efficacy of [18F]-2-fluoro-2-deoxy-D-glucose Positron Emission Tomography), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02208544 nacompletednot on this map

Efficacy of [18F]-2-fluoro-2-deoxy-D-glucose Positron Emission Tomography (FDG-PET) in Evaluation of Cytological Indeterminate Thyroid Nodules Prior to Surgery: a Multicentre Cost-effectiveness Study

TypeinterventionalSponsorRadboud University Medical CenterRan2015 to 2022Enrolled132ConditionsThyroid Nodule, Thyroid NeoplasmsArmsDiagnostic Thyroid Surgery, Ultrasound of the head and neck, FDG-PET/CT
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Molecular Diagnostics and [Thyroid : official journal of the American Thyroid Association · 2024
    Trial
  2. Article
  3. Article
  4. Model-based cost-effectiveness studies in nuclear medicine: an unavoidable fact of life.European journal of nuclear medicine and molecular imaging · 2025
    Article
  5. Article
  6. Role of [Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
  7. Cost-effectiveness of one-stop-shop [European journal of nuclear medicine and molecular imaging · 2024
    Article
  8. Endocrinology application of molecular imaging: current role of PET/CT.Journal of endocrinological investigation · 2024
    Review
  9. Review
  10. Review
  11. Preoperative stratification of cytologically indeterminate thyroid nodules by [European journal of nuclear medicine and molecular imaging · 2023
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Elizabeth J de KosterDepartment of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands. Lisanne.deKoster@radboudumc.nl.ORCID 0000-0001-8111-1172
Dennis VriensDepartment of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0001-5762-6766
Maarten O van AkenDepartment of Internal Medicine, Haga Hospital, The Hague, the Netherlands.ORCID 0000-0002-6686-5459
Lioe-Ting Dijkhorst-OeiDepartment of Internal Medicine, Meander Medical Centre, Amersfoort, the Netherlands.ORCID 0000-0001-7673-3743
Wim J G OyenDepartment of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands.ORCID 0000-0001-8235-7078
Robin P PeetersDepartment of Internal Medicine, Erasmus University Medical Centre, Rotterdam, the Netherlands.ORCID 0000-0001-7732-9371
Abbey SchepersDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0003-0504-3491
Lioe-Fee de Geus-OeiDepartment of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands.ORCID 0000-0003-1817-2743
Wilbert B van den HoutDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-6425-0135
EfFECTS trial study group
Leiden University Medical Center · NLRadboud University Nijmegen · NLErasmus University Rotterdam · NLHaga Hospital · NLHumanitas University · ITMeander Medisch Centrum · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate cost-effectiveness of an [

methodsLifelong societal costs and quality-adjusted life years (QALYs) were assessed for 132 patients participating in a randomised controlled multicentre trial comparing [

resultsThe observed 1-year cost difference of [

conclusionFollowing the observed reduction in diagnostic surgery, an [ TRIAL REGISTRATION NUMBER: This trial is registered with ClinicalTrials.gov: NCT02208544 (5 August 2014), https://clinicaltrials.gov/ct2/show/NCT02208544 .

Indexed as

Thyroid NoduleCost-Benefit AnalysisFluorodeoxyglucose F18HumansPositron Emission Tomography Computed TomographyQuality of LifeFluorodeoxyglucose F18[18F]FDG-PET/CTCost-effectivenessCostsHealth-related quality of lifeIndeterminate thyroid noduleQALYThyroid carcinomaThyroid surgery

Identifiers

PMID35435497
PMCPMC9308600
OpenAlexW4223920834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.