Evidence map›Paper›PMID 35435496›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

Infiltrative growth pattern of prostate cancer is associated with lower uptake on PSMA PET and reduced diffusion restriction on mpMRI.

Riccardo Laudicella, Jan H Rüschoff, Daniela A Ferraro, Muriel D Brada, Daniel Hausmann, Iliana Mebert, Alexander Maurer, Thomas Hermanns, Daniel Eberli, Niels J Rupp and 1 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Real-world outcomes of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Predictive imaging biomarkers on whole-body diffusion-weighted MRI (WB-DWMRI) and [Cancer imaging : the official publication of the International Cancer Imaging Society · 2026
    Article
  3. Article
  4. Article
  5. Multitracer comparison of gold standard PSMA-PET/CT withEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  6. Article
  7. Article
  8. The role of PSMA-based radioligand therapy in hormone-sensitive prostate cancer.European journal of nuclear medicine and molecular imaging · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. mCRPC progression of disease after [Urology case reports · 2024
    Article
  16. Diagnostic performance ofOncology letters · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. The Role of [Biomedicines · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

Riccardo Laudicella *Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Rämistrasse 10, 8091, Zurich, Switzerland.ORCID 0000-0002-2842-0301
Jan H Rüschoff *Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-1936-6606
Daniela A FerraroDepartment of Nuclear Medicine, University Hospital Zurich, University of Zurich, Rämistrasse 10, 8091, Zurich, Switzerland.ORCID 0000-0001-5707-3161
Muriel D BradaDepartment of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Daniel HausmannDepartment of Radiology, Kantonsspital Baden, Baden, Switzerland.
Iliana MebertDepartment of Nuclear Medicine, University Hospital Zurich, University of Zurich, Rämistrasse 10, 8091, Zurich, Switzerland.
Alexander MaurerDepartment of Nuclear Medicine, University Hospital Zurich, University of Zurich, Rämistrasse 10, 8091, Zurich, Switzerland.ORCID 0000-0002-6964-802X
Thomas HermannsDepartment of Urology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Daniel EberliDepartment of Urology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-8866-8010
Niels J Rupp *Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-7043-3456
Irene A Burger *Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Rämistrasse 10, 8091, Zurich, Switzerland. Irene.Burger@usz.ch.ORCID 0000-0001-8029-8692
University of Zurich · CHHeidelberg University · DEUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRecently, a significant association was shown between novel growth patterns on histopathology of prostate cancer (PCa) and prostate-specific membrane antigen (PSMA) uptake on [

methodsWe retrospectively evaluated patients who underwent [

resultsSixty-two patients were included (mean PSA 11.7 ± 12.5). The interrater agreement between both pathologists was almost perfect with κ = 0.81. While 25 lesions had an EXP-growth with an ADC

conclusionPCa with INF-growth showed significantly lower SUV

Indexed as

Multiparametric Magnetic Resonance ImagingProstatic NeoplasmsGallium RadioisotopesHumansMalePositron-Emission TomographyPositron Emission Tomography Computed TomographyRetrospective StudiesGallium RadioisotopesDiffusion-weighted imagingMRIProstate cancerPSMA PET/MRIRadical prostatectomy

Identifiers

PMID35435496
PMCPMC9399036
OpenAlexW4223891203

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.