Evidence map›Paper›PMID 35434940›Full record

Observational studyJournal of cachexia, sarcopenia and muscle2022

Upregulation of cluster of differentiation 36 mRNA expression in peripheral blood mononuclear cells correlates with frailty severity in older adults.

Chung-Sheng Lee, Chin-Hao Chang, Chin-Ying Chen, Chih-Yuan Shih, Jen-Kuei Peng, Hsien-Liang Huang, Pei-Yun Chen, Tse-Le Huang, Ching-Yu Chen, Jaw-Shiun Tsai

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Extensive longevity and DNA virus-driven adaptation in nearcticbioRxiv : the preprint server for biology · 2025
    Article
  5. Review
  6. Article
  7. Making Mountains out of Mole Hills: The Role of CD36 in Oxidized Phospholipid-driven Lung Injury.American journal of respiratory cell and molecular biology · 2024
    Article
  8. Review
  9. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Chung-Sheng LeeDepartment of Nutrition and Health Sciences, Kainan University, Taoyuan, Taiwan.
Chin-Hao ChangDepartment of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.
Chin-Ying ChenDepartment of Family Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chih-Yuan ShihDepartment of Family Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Jen-Kuei PengDepartment of Family Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Hsien-Liang HuangDepartment of Family Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Pei-Yun ChenDepartment of Family Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Tse-Le HuangDepartment of Family Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Ching-Yu ChenDepartment of Family Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Jaw-Shiun TsaiDepartment of Family Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0002-5227-8894
National Taiwan University · TWKainan University · TWNational Taiwan University Hospital · TW

Funding

Ministry of Science and Technology and the National Health Research Institute, Taiwan MOST 107-2314-B-002-273Ministry of Science and Technology and the National Health Research Institute, Taiwan MOST 108-2314-B-002-106Ministry of Science and Technology and the National Health Research Institute, Taiwan MOST 109-2314-B-002-165-MY3Ministry of Science and Technology and the National Health Research Institute, Taiwan NSC 98-2314-B-002-118-MY2Ministry of Science and Technology and the National Health Research Institute, Taiwan PH-098-PP-48
6 · The paper itself

Abstract

backgroundAging-associated frailty has been connected to low-grade chronic inflammation and also to progressive monocytic activation. CD36 (cluster of differentiation 36, platelet glycoprotein 4 or fatty acid translocase) has been shown to induce the expression of pro-inflammatory cytokines and to activate macrophage connected inflammation. This study aims to examine whether the expression of CD36 is up-regulated among frail older adults.

methodsThe demographic data, Fried Frailty Index, metabolic and inflammatory parameters of our observational study were obtained from the comprehensive geriatric assessment programme of a hospital-based outpatient department. The mRNA isolated from the peripheral blood mononuclear cells (PBMCs) was used to determine the levels of CD36, tumour necrosis factor alpha (TNF-α), and CXC chemokine ligand-10 (CXCL10) mRNAs with real-time polymerase chain reaction (PCR).

resultsA total of 189 older adults (58% female) were included in the analysis, and the mean age was 77.19 ± 6.12 years. The numbers of participants who fitted in the groups of robust, pre-frail, and frail were 46, 106, and 37, respectively. Our data showed that CD36 mRNA expression levels in PBMCs were the highest in the frail group (1.25 ± 0.53 in robust, 2.13 ± 1.02 in pre-frail, and 2.78 ± 1.15 in frail group, P < 0.001). Further regression analyses revealed that CD36 mRNA levels were positively correlated with both the pre-frail and frailty status in the univariate analysis (both P's < 0.001). What might suggest something worthy of further investigation is that, with potential confounders being adjusted for, CD36 remained as an independent factor that positively correlated with the pre-frail and frailty status in the multivariable analysis (P < 0.001).

conclusionsCD36 mRNA levels in PBMCs in robust older adults are significantly lower than in pre-frail and in frail. Our findings suggest that CD36 mRNA levels in PBMCs may be considered a potential biomarker for frail severity.

Indexed as

FrailtyAgedAged, 80 and overFemaleHumansInflammationLeukocytes, MononuclearMaleRNA, MessengerUp-RegulationRNA, MessengerBiomarkerCluster of differentiation 36CytokinesFrailty severityPeripheral blood mononuclear cells

Identifiers

PMID35434940
PMCPMC9178156
OpenAlexW4224025633

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.