Evidence map›Paper›PMID 35434688›Full record

ArticleThe Lancet regional health. Europe2022

Risk of strong antibody decline in dialysis and transplant patients after SARS-CoV-2mRNA vaccination: Six months data from the observational Dia-Vacc study.

Julian Stumpf, Jörg Schwöbel, Tom Lindner, Leona Anders, Torsten Siepmann, Claudia Karger, Jan Hüther, Heike Martin, Petra Müller, Robert Faulhaber-Walter and 27 more

Open access · goldAbstract read
In one paragraph

Article in The Lancet regional health. Europe, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 14 institutions in 1 country.

Julian StumpfMedizinische Klinik und Poliklinik III, Universitätsklinikum, Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Jörg SchwöbelDialysezentrum Chemnitz, Chemnitz, Germany.
Tom LindnerDivision of Nephrology, University Hospital Leipzig, Leipzig, Germany.
Leona AndersDialysepraxis Leipzig, Leipzig, Germany.
Torsten SiepmannKfH-Nierenzentrum am Klinikum Chemnitz, Krankenhaus Küchwald, Chemnitz, Germany.
Claudia KargerKfH-Nierenzentrum am Klinikum St. Georg, Leipzig, Germany.
Jan HütherNephrocare GmbH Döbeln, Döbeln, Germany.
Heike MartinNephrologisches Zentrum Zwickau, Zwickau, Germany.
Petra MüllerPHV Dialysezentrum Dresden-Johannstadt, Dresden, Germany.
Robert Faulhaber-WalterNephrologisches Zentrum Freiberg, Freiberg, Germany.
Torsten LangerDialysezentrum Annaberg, Annaberg-Buchholz, Germany.
Holger SchirutschkePHV Dialysezentrum Dresden Friedrichstadt, Dresden, Germany.
Thomas StehrKfH-Nierenzentrum Bautzen, Bautzen, Germany.
Frank MeistringKfH-Nierenzentrum am Städtischen Klinikum Görlitz, Görlitz, Germany.
Annegret PietzonkaVia medis Nierenzentrum Dresden MVZ GmbH, Dresden, Germany.
Kirsten Anding-RostKfH-Nierenzentrum Bischofswerda, Bischofswerda, Germany.
Katja EscherKfH-Gesundheitszentrum Aue, Aue-Bad-Schlema, Germany.
Frank PistroschNephrologisches Zentrum Hoyerswerda, Hoyerswerda, Germany.
Jens ScheweDialyse- und Nierenambulanz Sebnitz, Sebnitz, Germany.
Harald SeidelKfH-Nierenzentrum am Vogtland Krankenhaus Plauen, Plauen, Germany.
Kerstin BarnettDialyse Heidenau, Heidenau, Germany.
Thilo PluntkeKfH-Nierenzentrum Grimma, Grimma, Germany.
Simon CernyELBLAND Dialyse Großenhain, Großenhain, Germany.
Alexander PaliegeMedizinische Klinik und Poliklinik III, Universitätsklinikum, Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Ingolf BastDialysepraxis Leipzig, Leipzig, Germany.
Anne SteglichMedizinische Klinik und Poliklinik III, Universitätsklinikum, Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Florian GembardtMedizinische Klinik und Poliklinik III, Universitätsklinikum, Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Friederike KesselMedizinische Klinik und Poliklinik III, Universitätsklinikum, Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Hannah KrögerMedizinische Klinik und Poliklinik III, Universitätsklinikum, Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Patrick ArndtMedizinische Klinik und Poliklinik III, Universitätsklinikum, Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Jan SradnickMedizinische Klinik und Poliklinik III, Universitätsklinikum, Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Kerstin FrankInstitut für Transfusionsmedizin Plauen, DRK-Blutspendedienst Nord-Ost Gemeinnützige GmbH, Plauen, Germany.
Anna KlimovaNational Center for Tumor Diseases (NCT) Partner Site Dresden, Dresden, Germany.
René MauerFaculty of Medicine Carl Gustav Carus, Institute for Medical Informatics and Biometry (IMB), Technische Universität, Dresden, Germany.
Xina GrählertCoordinating Centre for Clinical Trials, Dresden, Germany.
Torsten TonnInstitute for Transfusion Medicine, German Red Cross Blood Donation Service North-East, Dresden, Germany.
Christian HugoMedizinische Klinik und Poliklinik III, Universitätsklinikum, Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Klinik und Poliklinik für Psychotherapie und Psychosomatik · DENierenzentrum Heidelberg · DEPHV Dialysezentrum · DEKlinikum Görlitz · DECarl Gustav Carus-Institut · DEDRK-Blutspendedienst Baden-Württemberg - Hessen · DEGerman Red Cross · DEKlinikum Chemnitz · DEKlinikum St. Georg · DENational Center for Tumor Diseases · DEnovacare (Germany) · DEUniversity Hospital Leipzig · DEVogtland-Klinik · DEWestsächsische Hochschule Zwickau · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vulnerable dialysis and kidney transplant patients show impaired seroconversion rates compared to medical personnel eight weeks after SARS-CoV-2mRNA vaccination. Methods: We evaluated six months follow up data in our observational Dia-Vacc study exploring specific cellular (interferon-γ release assay) or/and humoral immune responses after 2x SARS-CoV-2mRNA vaccination in 1205 participants including medical personnel (125 MP), dialysis patients (970 DP) and kidney transplant recipients (110 KTR) with seroconversion ( Findings: Six months after vaccination, seroconversion remained positive in 98% of MP, but 91%/87% of DP/KTR ( Interpretation: Both vulnerable DP and KTR groups are at risk for a strong decline for IgG and RBD antibodies. In KTR, antibody titres peak at a markedly lower level and accelerated antibody decline is mixed with a delayed/increasing IgG, RBD-IgG, or cellular immune response in a 16% fraction of patients. In both populations, immune monitoring should be used for early timing of additional booster vaccinations. Funding: This study was funded by the Else Kröner Fresenius Stiftung, Bad Homburg v. d. H., grant number Fördervertrag EKFS 2021_EKSE.27.

Indexed as

Antibody fadingDialysis patientsKidney transplant recipientsMedical personnelSARS-CoV-2mRNA vaccination

Identifiers

PMID35434688
PMCPMC8995854
OpenAlexW4223546254

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.