Evidence map›Paper›PMID 35434631›Full record

ArticleRSC medicinal chemistry2022

Identification of 2-arylquinazolines with alkyl-polyamine motifs as potent antileishmanial agents: synthesis and biological evaluation studies.

Anjila Kumari, Tara Jaiswal, Vinay Kumar, Neha Hura, Gulshan Kumar, Neerupudi Kishore Babu, Ayan Acharya, Pradyot K Roy, Sankar K Guchhait, Sushma Singh

Open access · greenAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Anjila KumariDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research S.A.S. Nagar 160062 India skguchhait@niper.ac.in.
Tara JaiswalDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research S.A.S. Nagar 160062 India skguchhait@niper.ac.in.
Vinay KumarDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research S.A.S. Nagar 160062 India sushmasingh@niper.ac.in.
Neha HuraDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research S.A.S. Nagar 160062 India skguchhait@niper.ac.in.
Gulshan KumarDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research S.A.S. Nagar 160062 India skguchhait@niper.ac.in.
Neerupudi Kishore BabuDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research S.A.S. Nagar 160062 India sushmasingh@niper.ac.in.
Ayan AcharyaDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research S.A.S. Nagar 160062 India skguchhait@niper.ac.in.ORCID https://orcid.org/0000-0003-4626-7694
Pradyot K RoyDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research S.A.S. Nagar 160062 India sushmasingh@niper.ac.in.
Sankar K GuchhaitDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research S.A.S. Nagar 160062 India skguchhait@niper.ac.in.ORCID https://orcid.org/0000-0002-1817-2172
Sushma SinghDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research S.A.S. Nagar 160062 India sushmasingh@niper.ac.in.
National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

2-Arylquinazolines with a range of alkyl polyamines as side chain/ring functional motifs at the 4th-position were considered for antileishmanial study with the rationale that related heterocyclic scaffolds and polyamine functionalities are present in drugs, clinical trial agents, natural products and anti-parasitic/leishmanial agents. Synthesis involves construction of the 2-arylquinazolin-4-one ring and deoxyamination

Identifiers

PMID35434631
PMCPMC8942235
OpenAlexW4206376572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.