Evidence map›Paper›PMID 35434624›Full record

ArticleRSC medicinal chemistry2022

Concise synthesis and biological activity evaluation of novel pyrazinyl-aryl urea derivatives against several cancer cell lines, which can especially induce T24 apoptotic and necroptotic cell death.

Jia-Nian Chen, Chu-Ting Chen, Yue-Zhen He, Tai-Sheng Qin, Li Cheng, Ye-Xiang Sun, Kang-Jian Yang, Qi Chen, Chao Yang, Ying Wei

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jia-Nian ChenState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University Yucai Road 15 Guilin 541004 Guangxi P.R. China cjn288@mailbox.gxnu.edu.cn cctichen@sina.com yzhe226@sina.com qintaisheng@sina.com missliesel@163.com wks72018@sina.com ykj01007@sina.com chen412qi@sina.com yangchao208509@sina.com weiying423@sina.com +86 0773 2120958 +86 0773 2120958.ORCID https://orcid.org/0000-0002-5551-8240
Chu-Ting ChenState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University Yucai Road 15 Guilin 541004 Guangxi P.R. China cjn288@mailbox.gxnu.edu.cn cctichen@sina.com yzhe226@sina.com qintaisheng@sina.com missliesel@163.com wks72018@sina.com ykj01007@sina.com chen412qi@sina.com yangchao208509@sina.com weiying423@sina.com +86 0773 2120958 +86 0773 2120958.
Yue-Zhen HeState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University Yucai Road 15 Guilin 541004 Guangxi P.R. China cjn288@mailbox.gxnu.edu.cn cctichen@sina.com yzhe226@sina.com qintaisheng@sina.com missliesel@163.com wks72018@sina.com ykj01007@sina.com chen412qi@sina.com yangchao208509@sina.com weiying423@sina.com +86 0773 2120958 +86 0773 2120958.
Tai-Sheng QinState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University Yucai Road 15 Guilin 541004 Guangxi P.R. China cjn288@mailbox.gxnu.edu.cn cctichen@sina.com yzhe226@sina.com qintaisheng@sina.com missliesel@163.com wks72018@sina.com ykj01007@sina.com chen412qi@sina.com yangchao208509@sina.com weiying423@sina.com +86 0773 2120958 +86 0773 2120958.
Li ChengState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University Yucai Road 15 Guilin 541004 Guangxi P.R. China cjn288@mailbox.gxnu.edu.cn cctichen@sina.com yzhe226@sina.com qintaisheng@sina.com missliesel@163.com wks72018@sina.com ykj01007@sina.com chen412qi@sina.com yangchao208509@sina.com weiying423@sina.com +86 0773 2120958 +86 0773 2120958.
Ye-Xiang SunState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University Yucai Road 15 Guilin 541004 Guangxi P.R. China cjn288@mailbox.gxnu.edu.cn cctichen@sina.com yzhe226@sina.com qintaisheng@sina.com missliesel@163.com wks72018@sina.com ykj01007@sina.com chen412qi@sina.com yangchao208509@sina.com weiying423@sina.com +86 0773 2120958 +86 0773 2120958.
Kang-Jian YangState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University Yucai Road 15 Guilin 541004 Guangxi P.R. China cjn288@mailbox.gxnu.edu.cn cctichen@sina.com yzhe226@sina.com qintaisheng@sina.com missliesel@163.com wks72018@sina.com ykj01007@sina.com chen412qi@sina.com yangchao208509@sina.com weiying423@sina.com +86 0773 2120958 +86 0773 2120958.
Qi ChenState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University Yucai Road 15 Guilin 541004 Guangxi P.R. China cjn288@mailbox.gxnu.edu.cn cctichen@sina.com yzhe226@sina.com qintaisheng@sina.com missliesel@163.com wks72018@sina.com ykj01007@sina.com chen412qi@sina.com yangchao208509@sina.com weiying423@sina.com +86 0773 2120958 +86 0773 2120958.
Chao YangState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University Yucai Road 15 Guilin 541004 Guangxi P.R. China cjn288@mailbox.gxnu.edu.cn cctichen@sina.com yzhe226@sina.com qintaisheng@sina.com missliesel@163.com wks72018@sina.com ykj01007@sina.com chen412qi@sina.com yangchao208509@sina.com weiying423@sina.com +86 0773 2120958 +86 0773 2120958.
Ying WeiState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University Yucai Road 15 Guilin 541004 Guangxi P.R. China cjn288@mailbox.gxnu.edu.cn cctichen@sina.com yzhe226@sina.com qintaisheng@sina.com missliesel@163.com wks72018@sina.com ykj01007@sina.com chen412qi@sina.com yangchao208509@sina.com weiying423@sina.com +86 0773 2120958 +86 0773 2120958.
Guangxi Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on the structural modification of regorafenib, 28 pyrazinyl-aryl urea derivatives were synthesized and their

Identifiers

PMID35434624
PMCPMC8942210
OpenAlexW3211731132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.