Evidence map›Paper›PMID 35434597›Full record

ArticleKidney medicine2022

Risk Prediction for Acute Kidney Injury in Patients Hospitalized With COVID-19.

Meredith C McAdams, Pin Xu, Sameh N Saleh, Michael Li, Mauricio Ostrosky-Frid, L Parker Gregg, Duwayne L Willett, Ferdinand Velasco, Christoph U Lehmann, S Susan Hedayati

Open access · goldAbstract read
In one paragraph

Article in Kidney medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Validation of a predictive model for hospital-acquired acute kidney injury with emergence of SARS-CoV-2 variants.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2023
    Article
  5. Observational
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Meredith C McAdamsDivision of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Pin XuDivision of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Sameh N SalehClinical Informatics Center, University of Texas Southwestern Medical Center, Dallas, TX.
Michael LiUniversity of Texas Southwestern College of Medicine, Dallas, TX.
Mauricio Ostrosky-FridDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
L Parker GreggSelzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, TX.
Duwayne L WillettDivision of Cardiology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Ferdinand VelascoTexas Health Resources, Dallas, TX.
Christoph U LehmannClinical Informatics Center, University of Texas Southwestern Medical Center, Dallas, TX.
S Susan HedayatiDivision of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
The University of Texas Southwestern Medical Center · USArizona Christian University · USHealth Services Research & Development · USTexas Health Resources Foundation · US

Funding

UT Southwestern Center for Translational MedicineUL1TR003163 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2021 to 2025
$39.3M
RENAL CONTROL OF BODY COMPOSITION AND BLOOD PRESSURET32DK007257 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BAUM, MICHEL GERARD, MOE, ORSON W · 1986 to 2021
$5.0M
Association of diuretics with change in extracellular volume, natriuretic peptides, symptoms, and cardiovascular outcomes in CKDIK2CX002368 · VA · MICHAEL E DEBAKEY VA MEDICAL CENTER · PI Lucile Parker Gregg · 2022 to 2027
–
CSRD VA IK2 CX002368NCATS NIH HHS UL1 TR003163NIDDK NIH HHS T32 DK007257
6 · The paper itself

Abstract

Rationale & Objective: Acute kidney injury (AKI) is common in patients hospitalized with COVID-19, but validated, predictive models for AKI are lacking. We aimed to develop the best predictive model for AKI in hospitalized patients with coronavirus disease 2019 and assess its performance over time with the emergence of vaccines and the Delta variant. Study Design: Longitudinal cohort study. Setting & Participants: Hospitalized patients with a positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction result between March 1, 2020, and August 20, 2021 at 19 hospitals in Texas. Exposures: Comorbid conditions, baseline laboratory data, inflammatory biomarkers. Outcomes: AKI defined by KDIGO (Kidney Disease: Improving Global Outcomes) creatinine criteria. Analytical Approach: Three nested models for AKI were built in a development cohort and validated in 2 out-of-time cohorts. Model discrimination and calibration measures were compared among cohorts to assess performance over time. Results: Of 10,034 patients, 5,676, 2,917, and 1,441 were in the development, validation 1, and validation 2 cohorts, respectively, of whom 776 (13.7%), 368 (12.6%), and 179 (12.4%) developed AKI, respectively ( Limitations: Potential billing and coding bias. Conclusions: We developed and externally validated a model to accurately predict AKI in patients with coronavirus disease 2019. The performance of the model withstood changes in practice patterns and virus variants.

Indexed as

Acute kidney injuryCOVID-19Delta variantmodel validationpredictive model

Identifiers

PMID35434597
PMCPMC8990440
OpenAlexW4224241316

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.