ArticleLaryngoscope investigative otolaryngology2022
Myopathy of the upper airway in snoring and obstructive sleep apnea.
Article in Laryngoscope investigative otolaryngology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Desmin is not ubiquitously expressed in head and neck muscle fibers.Journal of anatomy · 2026Article
- Risk of new-onset obstructive sleep apnea up to 4.5 years after COVID-19 in the urban population.Scientific reports · 2026Article
- The upper airway in obstructive sleep apnoea: state of the art.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Obstructive Sleep Apnea: The Expanding Role of Dental Sleep Medicine-A Systematic Review of Mandibular Advancement Devices, Treatment Efficacy, and Occlusal Complications.Dentistry journal · 2026Review
- Telemedicine-delivered myofunctional therapy remodels upper airway anatomy in obstructive sleep apnea: a prospective controlled study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Body Roundness Index Outperforms Body Mass Index in Predicting Obstructive Sleep Apnea Severity Among Chinese Adults.Journal of clinical medicine · 2025Article
- Tumors of the Parapharyngeal Space Presenting with Obstructive Sleep Apnea: A Case Report and Literature Review.Journal of personalized medicine · 2025Review
- Polysomnographic evaluation of sleep quality and quantitative variables in patients of hypothyroidism.Journal of family medicine and primary care · 2025Article
- Correlation Between Body-Shape Index, Body-Roundness Index, Body-Mass Index, and Apnea-Hypopnea Index in Patients with Obstructive Sleep Apnea Syndrome.Journal of multidisciplinary healthcare · 2025Article
- Desmin gene expression is not ubiquitous in all upper airway myofibers and the pattern differs between healthy and sleep apnea subjects.European journal of medical research · 2024Article
- Airways Type-2 Related Disorders: Multiorgan, Systemic or Syndemic Disease?International journal of molecular sciences · 2024Review
- The Effects of Orofacial Myofunctional Therapy on Children with OSAHS's Craniomaxillofacial Growth: A Systematic Review.Children (Basel, Switzerland) · 2023Review
- Myopathy of the upper airway in snoring and obstructive sleep apnea.Laryngoscope investigative otolaryngology · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Previous reports of muscle changes in the upper airways of obstructive sleep apnea (OSA) patients have primarily been attributed to acquired nerve lesions due to snoring vibrations. The aim of this study was to investigate whether alterations reflecting muscle fiber injuries also occur in the upper respiratory tract of snoring and OSA patients and if these changes relate to upper airway dysfunction. Methods: Muscle changes in biopsies from the soft palate of 20 patients suffering from snoring and OSA were investigated with enzyme, immunohistochemical, and morphometric techniques. Biopsies from eight healthy non-snoring subjects were used as controls. Swallowing dysfunction was assessed with videoradiography. Results: Fourteen patients had various degrees of swallowing dysfunction. The muscle samples from all the patients showed changes typical for both motor-nerve lesions and muscle fiber injuries. The most common alterations reflecting myopathy were fibers having aggregates and disorganization of cytoskeletal proteins (15.5 ± 10.7%). Other changes were fibers with vacuole-like structures (5.0 ± 4.4%), centrally positioned myonuclei (7.9 ± 4.8%), subsarcolemmal accumulations of nuclei, and various forms and sizes of ring fibers, that is, fibers where the myofilaments were disorganized peripherally (2.8 ± 2.8%). Conclusion: The results show that muscle changes mirroring both myopathy and neuropathy co-exist in the upper airway of snoring OSA patients. These findings suggest muscle weakness as a contributing factor to the upper airway dysfunction in OSA patients.
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