ReviewLaryngoscope investigative otolaryngology2022
Environmental air pollution and chronic rhinosinusitis: A systematic review.
Review in Laryngoscope investigative otolaryngology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Association between air pollution and allergic upper respiratory diseases: a meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Prevalence and risk factors of chronic rhinosinusitis among Chinese: A systematic review and meta-analysis.Frontiers in public health · 2022Pooled it
- Preoperative Pollen Exposure and Chronic Rhinosinusitis Outcomes After Endoscopic Sinus Surgery: A Pilot Investigation.Laryngoscope investigative otolaryngology · 2026Article
- Assessment of Lifetime Inhalational Exposure Burden and Associations With Chronic Rhinosinusitis.International forum of allergy & rhinology · 2026Article
- Effects of urban PM2.5 on primary sinonasal epithelial cells in individuals with chronic rhinosinusitis.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Pollen Exposure and Chronic Rhinosinusitis Quality of Life Disease Severity.Laryngoscope investigative otolaryngology · 2025Article
- Characterizing air pollution exposure methodologies in rhinology: a scoping review.International journal of environmental health research · 2025Article
- Article
- Deletion of Nrf2 Enhances Susceptibility to Sinonasal Inflammation After Short-Term PMInternational forum of allergy & rhinology · 2025Article
- Associations of environmental and community features with radiologic sinus inflammation in Pennsylvania, USA.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Sinusitis and rhinitis among US veterans deployed to Southwest Asia and Afghanistan after September 11, 2001.The journal of allergy and clinical immunology. Global · 2025Article
- Effects of meteorological factors on outpatient visits for chronic rhinosinusitis in Wuhan, China (2018-2019): a time-series analysis.Frontiers in public health · 2025Article
- Review
- Article
- The Effects of Environmental Factors on General Human Health: A Scoping Review.Healthcare (Basel, Switzerland) · 2024Article
- Health care disparities and chronic rhinosinusitis: Does neighborhood disadvantage impact outcomes in sinonasal disease?International forum of allergy & rhinology · 2024Article
- The Impact of Acute Peri-operative Particulate Matter Exposure on Endoscopic Sinus Surgery Outcomes: A Preliminary Multi-site Investigation.American journal of rhinology & allergy · 2024Article
- Does air pollutant exposure impact disease severity or outcomes in chronic rhinosinusitis?International forum of allergy & rhinology · 2024Article
- Chronic Rhinosinusitis-Microbiological Etiology, Potential Genetic Markers, and Diagnosis.International journal of molecular sciences · 2024Review
- Association between Chronic Kidney Disease and Chronic Rhinosinusitis: A Longitudinal Follow-Up Study Using a National Health Screening Cohort.Journal of personalized medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Objective: Chronic rhinosinusitis (CRS) is a highly prevalent and burdensome disease. The pathophysiology is not fully elucidated, but environmental pollutants have been suggested to impact the inflammatory component of the disease process. This review aims to summarize the role of environmental pollution in CRS onset and disease severity. Methods: A systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, EMBASE, Cochrane Library, Web of Science, and Scopus databases were queried in August 2021. Original articles reporting on air pollution exposure in CRS were included. Other forms of sinonasal disease were excluded. Results: Literature search produced 11,983 articles, of which 10 met inclusion criteria. Outcomes evaluated included incidence/prevalence, disease severity, quality of life, and histopathologic/microbial changes. Air pollutant exposure was associated with higher odds of CRS, particularly with particulate matter (PM) exposure. Increasing air pollution exposure was also associated with worsened disease severity and detectable histopathologic changes. Impact on quality of life was less clear. Conclusion: Air pollution (particularly PM) is correlated with CRS incidence/prevalence and disease severity, with evidence of histopathologic changes in CRS tissue samples. Further research is warranted to better understand the mechanisms by which air pollution components may cause CRS and type 2 inflammation. Level of Evidence: 3a.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.