ArticleAnnals of translational medicine2022
A new pyroptosis model can predict the immunotherapy response and immune microenvironment characteristics and prognosis of patients with cutaneous melanoma based on TCGA and GEO databases.
Article in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 15 citations in OpenAlex.
- Role of pyroptosis in melanoma: Molecular mechanisms and therapeutic potentials.Apoptosis : an international journal on programmed cell death · 2026Review
- Ferroptosis, pyroptosis, and necroptosis in melanoma: regulatory cell death pathways and their implications for immunotherapy.Frontiers in oncology · 2026Review
- Integrative analysis reveals prognostic value of cuproptosis and copper hemostasis related genes in immunotherapy for non-small cell lung cancer.NPJ precision oncology · 2025Article
- Doramectin Induces Apoptosis in B16 Melanoma Cells.Anti-cancer agents in medicinal chemistry · 2025Article
- C6 and KLRG2 are pyroptosis subtype-related prognostic biomarkers and correlated with tumor-infiltrating lymphocytes in lung adenocarcinoma.Scientific reports · 2024Article
- Engineering materials for pyroptosis induction in cancer treatment.Bioactive materials · 2024Review
- Melanoma biology and treatment: a review of novel regulated cell death-based approaches.Cancer cell international · 2024Review
- Multiomics characterization of pyroptosis in the tumor microenvironment and therapeutic relevance in metastatic melanoma.BMC medicine · 2024Article
- Construction of a novel prognostic model in skin cutaneous melanoma based on chemokines-related gene signature.Scientific reports · 2023Article
- [Cuproptosis-related immune gene signature predicts clinical benefits from anti-PD-1/PD-L1 therapy in non-small-cell lung cancer.Immunologic research · 2023Article
- Identification of a pyroptosis-based model for predicting clinical outcomes from immunotherapy in patients with metastatic melanoma.Cancer medicine · 2023Article
- The Therapeutic Potential of Pyroptosis in Melanoma.International journal of molecular sciences · 2023Review
- Construction and validation of a novel cuproptosis-mitochondrion prognostic model related with tumor immunity in osteosarcoma.PloS one · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Recent studies have shown that pyroptosis is related to cancer development. Our previous study also found that gasdermins (GSDMs) was associated with the tumor immune microenvironment. Therefore, we wanted to observe the relationship between pyroptosis and the immune microenvironment and prognosis of skin cutaneous melanoma (SKCM). Methods: Pyroptosis-related genes were used for pan-cancer prognostic analysis using the GEPIA2 online analysis website. Prognosis-related genes were clustered using R software and related R packages, and the best clustering results were screened for prognosis analysis. The prognosis-related genes were also used to establish a prognosis-related model. Assess the predictive power of a model by comparing area under the curve (AUC). The Results: By clustering the prognosis-related genes, SKCM could be divided into 2 clusters with significant differences in prognosis P<0.05. A prognostic model can be established using prognosis-related genes. The AUC value of 1 year, 2 years and 3 years was 0.696, 0.702 and 0.664, respectively. The risk score was significantly associated with prognosis in both univariate and multivariate Cox analyses P<0.001. The low-risk group or C2 cluster with better prognosis had higher expression of pyroptosis-related genes, and tended to have a lower exclusion score, greater chemokine expression, more immune cells and higher immune score. However, the C2 cluster or low-risk group was also associated with a higher dysfunction score. At the same time, the C2 or low-risk group was more suitable for immunotherapy because of the higher immunophenoscore (IPS) score P<0.001. Correlation analysis also demonstrated that the risk score was positively correlated with the gene expression of most immunoinhibitors, MHC molecules, immunostimulators, and chemokines and their receptors. Conclusions: Pyroptosis is associated with melanoma immune microenvironment, immunotherapy response, and prognoses. The constructed risk scores could effectively predict the characteristics of the immune microenvironment, the sensitivity to immunotherapy, and the prognosis of melanoma patients.
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