Evidence map›Paper›PMID 35434025›Full record

ArticleAnnals of translational medicine2022

Bromodomain containing 4 transcriptionally activated Deltex E3 ubiquitin ligase 2 contributes to glioma progression and predicts an unfavorable prognosis.

Shizhong Wu, Shang-Hang Shen, Feng Lu, Pengfeng Zheng, Kun Lin, Jingwei Liao, Xiaohang Jiang, Guangming Zeng, De Wei

Open access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
  6. [DTX2 overexpression promotes migration and invasion of colorectal cancer cells through the Notch2/Akt axis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Shizhong Wu *Department of Neurosurgery, Fujian Provincial Hospital South Branch, Fuzhou, China.
Shang-Hang Shen *Department of Neurosurgery, The First Affiliated Hospital of Xiamen University, Medical College of Xiamen University, Xiamen, China.
Feng LuDepartment of Neurosurgery, Fujian Provincial Hospital South Branch, Fuzhou, China.
Pengfeng ZhengDepartment of Neurosurgery, Fujian Provincial Hospital South Branch, Fuzhou, China.
Kun LinDepartment of Neurosurgery, Fujian Provincial Hospital South Branch, Fuzhou, China.
Jingwei LiaoDepartment of Neurosurgery, Fujian Provincial Hospital South Branch, Fuzhou, China.
Xiaohang JiangDepartment of Neurosurgery, Fujian Provincial Hospital South Branch, Fuzhou, China.
Guangming ZengDepartment of Neurosurgery, Fujian Provincial Hospital South Branch, Fuzhou, China.
De WeiDepartment of Neurosurgery, Fujian Provincial Hospital South Branch, Fuzhou, China.
Fujian Provincial Hospital · CNFirst Affiliated Hospital of Xiamen University · CNFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Glioblastoma multiforme (GBM) is the most common type of glioma, and the most aggressive brain malignancy in adults. This study sought to identify novel survival-status related markers, and examine their function in glioma. Methods: The gene expression, survival heatmaps, and Kaplan-Meier survival plots of the genes were analyzed by using gene expression profiling interactive analysis (GEPIA) dataset, Linked Omics. The single-cell data analysis and tumor immune infiltration analysis was conducted by Tumor Immune Estimation Resource (TIMER) dataset. DBTRG and U251 cells with silenced Deltex E3 ubiquitin ligase 2 ( Results: We first conducted a survival-status analysis to identify survival status-related genes in The Cancer Genome Atlas GBM and low-grade glioma data sets. A subsequent analysis identified 3 novel prognostic biomarkers; that is, Conclusions: In conclusion,

Indexed as

bromodomain containing 4 (BRD4)Deltex E3 ubiquitin ligase 2 (DTX2)Gliomasurvival status

Identifiers

PMID35434025
PMCPMC9011215
OpenAlexW4221090507

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.