Evidence map›Paper›PMID 35433850›Full record

ArticleFrontiers in cardiovascular medicine2022

The Histone Deacetylase 9 Stroke-Risk Variant Promotes Apoptosis and Inflammation in a Human iPSC-Derived Smooth Muscle Cells Model.

Alessandra Granata, Ioannis Kasioulis, Felipe Serrano, James D Cooper, Matthew Traylor, Sanjay Sinha, Hugh S Markus

Abstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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  6. Review
  7. Cerebrovascular Disorders.BMC cardiovascular disorders · 2023
    Article
  8. The Study of the Association of Polymorphisms inInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alessandra GranataStroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Ioannis KasioulisStroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Felipe SerranoAnne McLaren Laboratory, Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
James D CooperUK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Matthew TraylorQueen Mary University of London, London, United Kingdom.
Sanjay SinhaDepartment of Medicine, Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Hugh S MarkusStroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

Funding

British Heart Foundation FS/13/29/30024British Heart Foundation PG/18/80/34109Medical Research Council MC_PC_17230
6 · The paper itself

Abstract

A common variant in the Histone Deacetylase 9 (

Indexed as

HDAC9human induced pluripotent stem (hiPS) cellsischemic strokerisk variantsmooth muscle cells

Identifiers

PMID35433850
PMCPMC9005977

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.