Evidence map›Paper›PMID 35433789›Full record

ArticleFrontiers in nutrition2022

Short-Term Ketogenic Diet Induces a Molecular Response That Is Distinct From Dietary Protein Restriction.

Krystle C Kalafut, Sarah J Mitchell, Michael R MacArthur, James R Mitchell

Open access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Krystle C KalafutDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, United States.
Sarah J MitchellDepartment of Health Sciences and Technology, Swiss Federal Institute of Technology (ETH) Zürich, Zurich, Switzerland.
Michael R MacArthurDepartment of Health Sciences and Technology, Swiss Federal Institute of Technology (ETH) Zürich, Zurich, Switzerland.
James R MitchellDepartment of Health Sciences and Technology, Swiss Federal Institute of Technology (ETH) Zürich, Zurich, Switzerland.
ETH Zurich · CHHarvard University · US

Funding

Training Program in Molecular MetabolismT32DK128781 · NIDDK · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Sudha B Biddinger, GOKHAN S HOTAMISLIGIL · 2021 to 2026
$1.1M
NIDDK NIH HHS L40 DK065607NIDDK NIH HHS T32 DK128781
6 · The paper itself

Abstract

There is increasing interest in utilizing short-term dietary interventions in the contexts of cancer, surgical stress and metabolic disease. These short-term diets may be more feasible than extended interventions and may be designed to complement existing therapies. In particular, the high-fat, low-carbohydrate ketogenic diet (KD), traditionally used to treat epilepsy, has gained popularity as a potential strategy for weight loss and improved metabolic health. In mice, long-term KD improves insulin sensitivity and may extend lifespan and healthspan. Dietary protein restriction (PR) causes increased energy expenditure, weight loss and improved glucose homeostasis. Since KD is inherently a low-protein diet (10% of calories from protein vs. >18% in control diet), here we evaluated the potential for mechanistic overlap between PR and KD

Indexed as

carbohydratecarbohydrate restrictiondietary restrictionketogeniclow proteinproteinprotein restrictionRNA seq

Identifiers

PMID35433789
PMCPMC9005751
OpenAlexW4225794054

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.