Evidence map›Paper›PMID 35433754›Full record

ArticleFrontiers in medicine2022

Development of a Machine Learning-Based Predictive Model for Lung Metastasis in Patients With Ewing Sarcoma.

Wenle Li, Tao Hong, Wencai Liu, Shengtao Dong, Haosheng Wang, Zhi-Ri Tang, Wanying Li, Bing Wang, Zhaohui Hu, Qiang Liu and 2 more

Abstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Multimodality treatment and survival in primary cardiac malignancies: evidence from competing-risk and machine learning analyses.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Interpretable Machine Learning Approach for Predicting 30-Day Mortality of Critical Ill Patients with Pulmonary Embolism and Heart Failure: A Retrospective Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenle LiDepartment of Orthopedics, Xianyang Central Hospital, Xianyang, China.
Tao HongDepartment of Cardiac Surgery, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, Shenzhen, China.
Wencai LiuDepartment of Orthopaedic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, China.
Shengtao DongDepartment of Spine Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Haosheng WangDepartment of Orthopaedics, The Second Hospital of Jilin University, Changchun, China.
Zhi-Ri TangSchool of Physics and Technology, Wuhan University, Wuhan, China.
Wanying LiClinical Medical Research Center, Xianyang Central Hospital, Xianyang, China.
Bing WangClinical Medical Research Center, Xianyang Central Hospital, Xianyang, China.
Zhaohui HuDepartment of Spinal Surgery, Liuzhou People's Hospital, Liuzhou, China.
Qiang LiuDepartment of Orthopedics, Xianyang Central Hospital, Xianyang, China.
Yong QinDepartment of Orthopedics Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Chengliang YinFaculty of Medicine, Macau University of Science and Technology, Macau, Macau SAR, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aimed to develop and validate machine learning (ML)-based prediction models for lung metastasis (LM) in patients with Ewing sarcoma (ES), and to deploy the best model as an open access web tool. Methods: We retrospectively analyzed data from the Surveillance Epidemiology and End Results (SEER) Database from 2010 to 2016 and from four medical institutions to develop and validate predictive models for LM in patients with ES. Patient data from the SEER database was used as the training group ( Results: The study cohort consisted of 929 patients from the SEER database and 51 patients from multiple medical centers, a total of 980 ES patients. Of these, 175 (18.8%) had lung metastasis. Multivariate logistic regression analysis was performed with survival time, T-stage, N-stage, surgery, and bone metastasis providing the independent predictive factors of LM. The AUC value of six predictive models ranged from 0.585 to 0.705. The Random Forest (RF) model ( Conclusions: Machine learning were found to have utility for predicting LM in patients with Ewing sarcoma, and the RF model gave the best performance. The accessibility of the predictive model as a web-based tool offers clear opportunities for improving the personalized treatment of patients with ES.

Indexed as

Ewing sarcomalung metastasismachine learning algorithmsmulticenterweb calculator

Identifiers

PMID35433754
PMCPMC9011057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.