Evidence map›Paper›PMID 35433750›Full record

ArticleFrontiers in medicine2022

Expert Recommendations on the Evaluation of Sunscreen Efficacy and the Beneficial Role of Non-filtering Ingredients.

Salvador González, José Aguilera, Brian Berman, Piergiacomo Calzavara-Pinton, Yolanda Gilaberte, Chee-Leok Goh, Henry W Lim, Sergio Schalka, Fernando Stengel, Peter Wolf and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Properties of Aspalathus linearis extracts as sunscreen agents in combination with standard UV filters.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  3. Exploring the In Vitro Photoprotective Effect of a Combination ofInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Clinical Applications ofLife (Basel, Switzerland) · 2023
    Review
  10. Review
  11. Focus on the Contribution of Oxidative Stress in Skin Aging.Antioxidants (Basel, Switzerland) · 2022
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 7 countries.

Salvador GonzálezMedicine and Medical Specialties Department, University of Alcalá de Henares, Madrid, Spain.
José AguileraDermatological Photobiology Laboratory, Medical Research Center, School of Medicine, University of Málaga, Málaga, Spain.
Brian BermanDepartment of Dermatology and Cutaneous Surgery, University of Miami-Florida, Miami, FL, United States.
Piergiacomo Calzavara-PintonDepartment of Dermatology, University of Brescia, Brescia, Italy.
Yolanda GilaberteDepartment of Dermatology, Hospital Universitario Miguel Servet, IIS Aragón, Zaragoza, Spain.
Chee-Leok GohNational Skin Centre, Singapore, Singapore.
Henry W LimDepartment of Dermatology, Henry Ford Health System, Detroit, MI, United States.
Sergio SchalkaPhotoprotection Laboratory, Medicine Skin Research Center, São Paulo, Brazil.
Fernando StengelBuenos Aires Skin, Buenos Aires, Argentina.
Peter WolfDepartment of Dermatology, Medical University of Graz, Graz, Austria.
Flora XiangDepartment of Dermatology, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, China.
Henry Ford Health System · USHospital Universitario Miguel Servet · ESHuashan Hospital · CNMedical University of Graz · ATNational Skin Centre · SGSkin Research Center · FRUniversidad de Alcalá · ESUniversidad de Málaga · ESUniversity of Brescia · ITUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A variety of non-filtering agents have been introduced to enhance sunscreen photoprotection. Most of those agents have only weak erythema protective properties but may be valuable and beneficial in supporting protection against other effects of UV radiation, such as photoimmunosuppression, skin aging, and carcinogenesis, as well as photodermatoses. The question arises how to measure and evaluate this efficacy since standard SPF testing is not appropriate. In this perspective, we aim to provide a position statement regarding the actual value of SPF and UVA-PF to measure photoprotection. We argue whether new or additional parameters and scales can be used to better indicate the protection conferred by these products against the detrimental effects of natural/artificial, UV/visible light beyond sunburn, including DNA damage, photoimmunosuppression and pigmentation, and the potential benefits of the addition of other ingredients beyond traditional inorganic and organic filters to existing sunscreens. Also, we debate the overall usefulness of adding novel parameters that measure photoprotection to reach two tiers of users, that is, the general public and the medical community; and how this can be communicated to convey the presence of additional beneficial effects deriving from non-filtering agents, e.g., biological extracts. Finally, we provide a perspective on new challenges stemming from environmental factors, focusing on the role of the skin microbiome and the role of air pollutants and resulting needs for photoprotection.

Indexed as

ISOphotoprotectionpolypodium leucomotosskin immunitysunscreenUV

Identifiers

PMID35433750
PMCPMC9008233
OpenAlexW4221068016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.