Evidence map›Paper›PMID 35433718›Full record

ArticleFrontiers in medicine2022

Dogs Detecting COVID-19 From Sweat and Saliva of Positive People: A Field Experience in Mexico.

Juan Manuel Mancilla-Tapia, Victoria Lozano-Esparza, Adrián Orduña, Reyna Fabiola Osuna-Chávez, Ramón Enrique Robles-Zepeda, Blayra Maldonado-Cabrera, Jorge Rubén Bejar-Cornejo, Iván Ruiz-León, Carlos Gabriel González-Becuar, Anna Hielm-Björkman and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Juan Manuel Mancilla-TapiaCanine Training Center Obi-K19, Hermosillo, Mexico.
Victoria Lozano-EsparzaCanine Training Center Obi-K19, Hermosillo, Mexico.
Adrián OrduñaCanine Training Center Obi-K19, Hermosillo, Mexico.
Reyna Fabiola Osuna-ChávezDivisión de Ciencias Biológicas y de la Salud, Departamento de Agricultura y Ganadería, Universidad de Sonora, Hermosillo, Mexico.
Ramón Enrique Robles-ZepedaDivisión de Ciencias Biológicas y de la Salud, Departamento de Agricultura y Ganadería, Universidad de Sonora, Hermosillo, Mexico.
Blayra Maldonado-CabreraDivisión de Ciencias Biológicas y de la Salud, Departamento de Agricultura y Ganadería, Universidad de Sonora, Hermosillo, Mexico.
Jorge Rubén Bejar-CornejoHospital General del Estado de Sonora, Secretaria de Salud Pública del Estado de Sonora, Hermosillo, Mexico.
Iván Ruiz-LeónHospital General del Estado de Sonora, Secretaria de Salud Pública del Estado de Sonora, Hermosillo, Mexico.
Carlos Gabriel González-BecuarHospital General del Estado de Sonora, Secretaria de Salud Pública del Estado de Sonora, Hermosillo, Mexico.
Anna Hielm-BjörkmanDepartment of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Ana Novelo-GonzálezLaboratorio de Patología Acuática, Departamento de Recursos del Mar, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Unidad Mérida, Mérida, Mexico.
Victor Manuel Vidal-MartínezLaboratorio de Patología Acuática, Departamento de Recursos del Mar, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Unidad Mérida, Mérida, Mexico.
Secretaria de Salud · MXUniversidad de Sonora · MXInstituto Politécnico Nacional · MXUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: Molecular tests are useful in detecting COVID-19, but they are expensive in developing countries. COVID-19-sniffing dogs are an alternative due to their reported sensitivity (>80%) and specificity (>90%). However, most of the published evidence is experimental, and there is a need to determine the performance of the dogs in field conditions. Hence, we aimed to test the sensitivity and specificity of COVID-19-sniffing dogs in the field. Methods: We trained four dogs with sweat and three dogs with saliva of COVID-19-positive patients, respectively, for 4.5 months. The samples were obtained from a health center in Hermosillo, Sonora, with the restriction to spend 5 min per patient. We calculated sensitivity, specificity, and their 95% confidence intervals (CI). Results: Two sweat-sniffing dogs reached 76 and 80% sensitivity, with the 95% CI not overlapping the random value of 50%, and 75 and 88% specificity, with the 95% CI not overlapping the 50% value. The 95% CI of the sensitivity and specificity of the other two sweat dogs overlapped the 50% value. Two saliva-sniffing dogs had 70 and 78% sensitivity, and the 95% CI of their sensitivity and specificity did not overlap the 50% value. The 95% CI of the third dog's sensitivity and specificity overlapped the 50% value. Conclusion: Four of the six dogs were able to detect positive samples of patients with COVID-19, with sensitivity and specificity values significantly different from random in the field. We considered the performance of the dogs promising because it is reasonable to expect that with gauze exposed for a longer time to sweat and saliva of people with COVID-19, their detection capacity would improve. The target is to reach the sensitivity range requested by the World Health Organization for the performance of an antigen test (≥80% sensitivity, ≥97% specificity). If so, dogs could become important allies for the control of the COVID-19 pandemic, especially in developing countries.

Indexed as

bio-detectionCOVID-19dog trainingMexicoolfactory detectionpathogen detectionSARS-CoV-2sniffing dogs

Identifiers

PMID35433718
PMCPMC9012113
OpenAlexW4221136267

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.