Evidence map›Paper›PMID 35433510›Full record

ArticleFrontiers in cellular and infection microbiology2022

Vimentin Inhibits Dengue Virus Type 2 Invasion of the Blood-Brain Barrier.

Jianhai Yu, Xujuan Li, Dongrui Zhou, Xuling Liu, Xiaoen He, Sheng-He Huang, Qinghua Wu, Li Zhu, Linzhong Yu, Jinxiu Yao and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Risk of cognitive decline among patients with dengue virus infection: a systematic review.The international journal of neuropsychopharmacology · 2024
    Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Jianhai YuBiological Safety Laboratory of Level 3 (BSL-3) Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Xujuan LiBiological Safety Laboratory of Level 3 (BSL-3) Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Dongrui ZhouBiological Safety Laboratory of Level 3 (BSL-3) Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Xuling LiuBiological Safety Laboratory of Level 3 (BSL-3) Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Xiaoen HeBiological Safety Laboratory of Level 3 (BSL-3) Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Sheng-He HuangSaban Research Institute of Children's Hospital Los Angeles, Department of Pediatrics, University of Southern California, Los Angeles, CA, United States.
Qinghua WuBiological Safety Laboratory of Level 3 (BSL-3) Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Li ZhuBiological Safety Laboratory of Level 3 (BSL-3) Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Linzhong YuDepartment of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Jinxiu YaoDepartment of Laboratory, People's Hospital of Yangjiang, Yangjiang, China.
Bao ZhangBiological Safety Laboratory of Level 3 (BSL-3) Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Wei ZhaoBiological Safety Laboratory of Level 3 (BSL-3) Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Southern Medical University · CNPeople's Hospital of Yangzhong · CNUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue virus (DENV) causes dengue fever, which is prevalent in the tropical and subtropical regions, and in recent years, has resulted in several major epidemics. Vimentin, a cytoskeletal component involved in DENV infection, is significantly reorganized during infection. However, the mechanism underlying the association between DENV infection and vimentin is still poorly understood. We generated vimentin-knockout (Vim-KO) human brain microvascular endothelial cells (HBMECs) and a Vim-KO SV129 suckling mouse model, combining the dynamic vimentin changes observed

Indexed as

DengueDengue VirusAnimalsBlood-Brain BarrierEndothelial CellsHumansMiceMice, KnockoutVimentinVimentinVIM protein, humanVim protein, mousedengue virushuman brain microvascular endothelial cellsinhibitionSV129 micevimentin

Identifiers

PMID35433510
PMCPMC9005901
OpenAlexW4220977770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.