ArticleWorld journal of psychiatry2022
Does COVID-19 increase the risk of neuropsychiatric sequelae? Evidence from a mendelian randomization approach.
Article in World journal of psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- The Omics Landscape of Long COVID-A Comprehensive Systematic Review to Advance Biomarker, Target and Drug Discovery.Allergy · 2025Pooled it
- Shared Genetic Architecture Between COVID-19 Severity and Alzheimer's Disease Across European and African Ancestries.Research square · 2024Article
- Causal effect of COVID-19 on longitudinal volumetric changes in subcortical structures: A mendelian randomization study.Heliyon · 2024Article
- Unmasking the long-term effects: unravelling neuropsychiatric and neurological consequences of COVID-19.Annals of medicine and surgery (2012) · 2024Review
- A Prospective Multicenter Longitudinal Analysis of Suicidal Ideation among Long-COVID-19 Patients.Healthcare (Basel, Switzerland) · 2024Article
- Anxiety in post-covid-19 syndrome - prevalence, mechanisms and treatment.Neuroscience applied · 2024Review
- Externalizing traits: Shared causalities for COVID-19 and Alzheimer's dementia using Mendelian randomization analysis.PNAS nexus · 2023Article
- Association of COVID-19 with Risk and Progression of Alzheimer's Disease: Non-Overlapping Two-Sample Mendelian Randomization Analysis of 2.6 Million Subjects.Journal of Alzheimer's disease : JAD · 2023Article
- Association of Acute Headache of COVID-19 and Anxiety/Depression Symptoms in Adults Undergoing Post-COVID-19 Rehabilitation.Journal of clinical medicine · 2022Article
- Dimensions of emotional distress among Brazilian workers in a COVID-19 reference hospital: A factor analytical study.World journal of psychiatry · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Observational studies based on electronic health records (EHR) report an increased risk of neurological/neuropsychiatric sequelae for patients who have had coronavirus disease 2019 (COVID-19). However, these studies may suffer from biases such as unmeasured confounding, residual reverse causality, or lack of precision in EHR-based diagnoses. To rule out these biases, we tested causal links between COVID-19 and different potential neurological/neuropsychiatric sequelae through a two-sample Mendelian randomization analysis of summary statistics from large Genome-Wide Association Scans of susceptibility to COVID-19 and different neurological and neuropsychiatric disorders, including major depression, anxiety, schizophrenia, stroke, Parkinson's and Alzheimer's diseases. We found robust evidence suggesting that COVID-19 - notably the hospitalized and most severe forms - carries an increased risk of neuropsychiatric sequelae, particularly Alzheimer's disease, and to a lesser extent anxiety disorder. In line with a large longitudinal EHR-based study, this evidence was stronger for more severe COVID-19 forms. These results call for a targeted screening strategy to tackle the post-COVID neuropsychiatric pandemic.
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