Evidence map›Paper›PMID 35433297›Full record

ReviewWorld journal of clinical pediatrics2022

Druggable monogenic immune defects hidden in diverse medical specialties: Focus on overlap syndromes.

Valentina Boz, Chiara Zanchi, Laura Levantino, Guglielmo Riccio, Alberto Tommasini

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of clinical pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Immunogenetic Landscape in Pediatric Common Variable Immunodeficiency.International journal of molecular sciences · 2024
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Valentina BozDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste 34137, Italy.
Chiara ZanchiDepartment of Pediatrics, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste 34137, Italy.
Laura LevantinoDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste 34137, Italy.
Guglielmo RiccioDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste 34137, Italy.
Alberto TommasiniDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste 34137, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last two decades two new paradigms changed our way of perceiving primary immunodeficiencies: An increasing number of immune defects are more associated with inflammatory or autoimmune features rather than with infections. Some primary immune defects are due to hyperactive pathways that can be targeted by specific inhibitors, providing innovative precision treatments that can change the natural history of diseases. In this article we review some of these "druggable" inborn errors of immunity and describe how they can be suspected and diagnosed in diverse pediatric and adult medicine specialties. Since the availability of precision treatments can dramatically impact the course of these diseases, preventing the development of organ damage, it is crucial to widen the awareness of these conditions and to provide practical hints for a prompt detection and cure.

Indexed as

AutoimmunityImmunodysregulationInborn errors of immunityOverlap syndromesPrecision treatmentsPrimary immunodeficiency diseases

Identifiers

PMID35433297
PMCPMC8985491

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.