Evidence map›Paper›PMID 35433269›Full record

ArticleJournal of clinical & translational endocrinology2022

Interleukin-8, CXCL10, CXCL11 and their role in insulin resistance in adult females with subclinical hypothyroidism and prediabetes.

Roxana Adriana Stoica, Nicoleta Drăgana, Robert Ancuceanu, Ovidiu Ionuț Geicu, Cristian Guja, Anca Pantea-Stoian, Damaris-Cristina Gheorghe, Raluca-Ioana Stefan-van Staden, Cristian Serafinceanu, Adrian Costache and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical & translational endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Endocrine-Metabolic Crosstalk Between Diabetes Mellitus and Hypothyroidism: From Network Mechanisms to Translational Stratification.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  3. Role of Interleukins in Type 1 and Type 2 Diabetes.Diagnostics (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Roxana Adriana StoicaDepartment of Diabetes, Nutrition and Metabolic Diseases, "Carol Davila" University of Medicine and Pharmacy, 020475 Bucharest, Romania.
Nicoleta Drăgana"Francisc I. Rainer" Anthropological Research Centre, Romanian Academy, 076241 Bucharest, Romania.
Robert AncuceanuDepartment of Botanical Pharmaceutics, "Carol Davila" University of Medicine and Pharmacy, 020956 Bucharest, Romania.
Ovidiu Ionuț GeicuDepartment of Preclinical Sciences, University of Agricultural Sciences and Veterinary Medicine of Bucharest, 011464 Bucharest, Romania.
Cristian GujaDepartment of Diabetes, Nutrition and Metabolic Diseases, "Carol Davila" University of Medicine and Pharmacy, 020475 Bucharest, Romania.
Anca Pantea-StoianDepartment of Diabetes, Nutrition and Metabolic Diseases, "Carol Davila" University of Medicine and Pharmacy, 020475 Bucharest, Romania.
Damaris-Cristina GheorgheLaboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, 060021 Bucharest, Romania.
Raluca-Ioana Stefan-van StadenLaboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, 060021 Bucharest, Romania.
Cristian SerafinceanuDepartment of Diabetes, Nutrition and Metabolic Diseases, "Carol Davila" University of Medicine and Pharmacy, 020475 Bucharest, Romania.
Adrian CostacheDepartment of Pathology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Constantin Ionescu-TîrgovișteDepartment of Diabetes, Nutrition and Metabolic Diseases, "Carol Davila" University of Medicine and Pharmacy, 020475 Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy · RONational Institute of Research and Development for Electrochemistry and Condensed · RORomanian Academy · ROUniversity of Agronomic Sciences and Veterinary Medicine of Bucharest · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In obesity, the hormonal secretion of the thyroid gland switches from homeostasis to type 2 allostasis in order to adapt to persistent modifications of adipose tissue and inflammation. Previous meta-analyses have linked obesity with an increased risk of developing thyroid diseases, prediabetes, and type 2 diabetes mellitus. We designed an observational cross-sectional study including all female patients presenting consecutively in an ambulatory clinic for 16 months. This study aimed to describe the level of serum cytokines and chemokines in relation to TSH, fT4 and insulin resistance (IR) indexes in patients with subclinical hypothyroidism (SCH). The study included 72 women with a median age of 59 ± 17.75 years, and a mean BMI (Body Mass Index) of 31.48 ± 6.75 kg/m

Indexed as

ChemokinesCXCL10CXCL11HypothyroidismInsulin resistanceInterleukin-8Prediabetes

Identifiers

PMID35433269
PMCPMC9006329
OpenAlexW4224222693

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.