Evidence map›Paper›PMID 35433160›Full record

ArticleBioscience of microbiota, food and health2022

Local free fatty acids trigger the expression of lipopolysaccharide-binding protein in murine white adipose tissue.

Manami Seki, Akiho Miwa, Fumina Ohsaka, Yugo Karatsu, Takeshi Tsuruta, Shingo Hino, Tatsuya Morita, Kei Sonoyama

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience of microbiota, food and health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Mechanisms of Oxidative Stress in Metabolic Syndrome.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Manami SekiGraduate School of Life Science, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo 060-8589, Japan.
Akiho MiwaGraduate School of Life Science, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo 060-8589, Japan.
Fumina OhsakaGraduate School of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo 060-8589, Japan.
Yugo KaratsuGraduate School of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo 060-8589, Japan.
Takeshi TsurutaGraduate School of Environmental and Life Science, Okayama University, 2-1-1 Tsushima-Naka, Kita-ku, Okayama-shi, Okayama 700-8530, Japan.
Shingo HinoCollege of Agriculture, Academic Institute, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka-shi, Shizuoka 422-8529, Japan.
Tatsuya MoritaCollege of Agriculture, Academic Institute, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka-shi, Shizuoka 422-8529, Japan.
Kei SonoyamaResearch Faculty of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo 060-8589, Japan.
Hokkaido University · JPShizuoka University · JPOkayama University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although lipopolysaccharide (LPS)-binding protein (LBP) is an acute-phase protein mainly produced by hepatocytes, it has also been proposed to be a pro-inflammatory adipokine. Obesity and the consumption of a high-fat diet (HFD) are reportedly associated with elevated levels of LPS in plasma and free fatty acids (FFAs) in white adipose tissue (WAT). We examined whether circulating LPS or local FFAs are responsible for the HFD-induced increase of LBP in WAT. Male C57BL/6J mice were fed either a normal-fat diet (NFD) or an HFD. The mRNA levels in the liver and mesenteric WAT (mWAT), total FFA content in mWAT, and LBP and LPS concentrations in plasma were determined. The

Indexed as

high-fat dietinflammationlipopolysaccharide-binding proteinwhite adipose tissue

Identifiers

PMID35433160
PMCPMC8970656
OpenAlexW4210760379

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.