ArticleChemical science2022
Chiral proline-substituted porous organic cages in asymmetric organocatalysis.
Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Confined Cationic Covalent Organic Cages Enable Oxidant-Free Hofmann-Löffler-Freytag/Cyclization Sequences.Angewandte Chemie (International ed. in English) · 2026Article
- Attractive Noncovalent Interactions versus Steric Confinement in Asymmetric Supramolecular Catalysis.Journal of the American Chemical Society · 2026Article
- Ionic organic cage as a versatile platform for immobilizing chemical and enzymatic sites for chemoenzymatic catalysis.Nature communications · 2025Article
- Heterogeneous organocatalysis: the proline case.RSC advances · 2025Review
- Chiral covalent organic cages: Construction and chiral functions.Smart molecules : open access · 2025Review
- Beyond symmetric self-assembly and effective molarity: unlocking functional enzyme mimics with robust organic cages.Beilstein journal of organic chemistry · 2025Article
- Adsorptive Separation of Methylfuran and Dimethylfuran by a Robust Porous Organic Cage.Chem & bio engineering · 2024Article
- A general large-scale synthesis approach for crystalline porous materials.Nature communications · 2023Article
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Authors and funding
5 authors.
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Abstract
The efficient preparation of chiral porous organic cages (POCs) with specific functions is challenging, and their application in asymmetric catalysis has not previously been explored. In this work, we have achieved the construction of chiral POCs based on a supramolecular tetraformyl-resorcin[4]arene scaffold with different chiral proline-modified diamine ligands and utilizing dynamic imine chemistry. The incorporation of V-shaped or linear chiral diamines affords the [4 + 8] square prism and [6 + 12] octahedral POCs respectively. The appended chiral proline moieties in such POCs make them highly active supramolecular nanoreactors for asymmetric aldol reactions, delivering up to 92% ee. The spatial distribution of chiral catalytic sites in these two types of POCs greatly affects their catalytic activities and enantioselectivities. This work not only lays a foundation for the asymmetric catalytic application of chiral POCs, but also contributes to our understanding of the catalytic function of biomimetic supramolecular systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.