Evidence map›Paper›PMID 35432786›Full record

ArticleComputational and structural biotechnology journal2022

Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2.

Harry Ridgway, Graham J Moore, Thomas Mavromoustakos, Sotirios Tsiodras, Irene Ligielli, Konstantinos Kelaidonis, Christos T Chasapis, Laura Kate Gadanec, Anthony Zulli, Vasso Apostolopoulos and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Unlocking Novel Therapeutic Potential of Angiotensin II Receptor Blockers.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Implications of SARS-CoV-2 spike protein interactions with Zn-bound form of ACE2: a computational structural study.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Harry RidgwayInstitute for Sustainable Industries and Liveable Cities, Victoria University, Melbourne, Australia.
Graham J MoorePepmetics Inc., 772 Murphy Place, Victoria, BC V6Y 3H4, Canada.
Thomas MavromoustakosDepartment of Chemistry, National Kapodistrian University of Athens, Greece.
Sotirios TsiodrasFaculty of Medicine, 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Irene LigielliDepartment of Chemistry, National Kapodistrian University of Athens, Greece.
Konstantinos KelaidonisNewDrug PC, Patras Science Park, Patras, 26504, Greece.
Christos T ChasapisNMR Facility, Instrumental Analysis Laboratory, School of Natural Sciences, University of Patras, Patras, Greece.
Laura Kate GadanecInstitute for Health and Sport, Victoria University, Melbourne, VIC 3030 Victoria, Australia.
Anthony ZulliInstitute for Health and Sport, Victoria University, Melbourne, VIC 3030 Victoria, Australia.
Vasso ApostolopoulosInstitute for Health and Sport, Victoria University, Melbourne, VIC 3030 Victoria, Australia.
Russell PettyNinewells Hospital and Medical School, University of Dundee, Dundee, UK.
Ioannis KarakasiliotisLaboratory of Biology, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Vassilis G GorgoulisNinewells Hospital and Medical School, University of Dundee, Dundee, UK.
John M MatsoukasDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Alberta T2N 4N1, Canada.
National and Kapodistrian University of Athens · GRVictoria University · AUUniversity of Calgary · CAUniversity of Dundee · GBAustralian Institute for Musculoskeletal Science · AUDemocritus University of Thrace · GRUniversity of Patras · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The discovery and facile synthesis of a new class of sartan-like arterial antihypertensive drugs (angiotensin receptor blockers [ARBs]), subsequently referred to as "bisartans" is reported.

Indexed as

Angiotensin receptorsAnimal AT1 receptor studiesAzil, AzilsartanBisA, 4-Butyl-N,N0-bis{[[20-(2H-tetrazol-5-yl)]biphenyl-4-yl] methyl}imidazolium bromideBisartan NMR studiesBisartans tetrazoleBisB, 4-Butyl-2-hydroxymethyl-N,N0-bis{[20-(2H-tetrazol-5-yl)- biphenyl-4-yl]methyimidazolium bromideBisC, 2-Butyl-4-chloro-5-hydroxymethyl-N,N0-bis{[20-(2H-tetrazol- 5-yl)biphenyl-4-yl]methyl}imidazolium bromideBisD, 2-Butyl-N,N0-bis{[20-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl} imidazolium bromideCande, CandesartanDIZE, deminazene aceturateDocking RBD/ACE2 studiesEpro, EprosartanEXP3174, losartan carboxylic acidIrbe, IrbesartanLo, LosartanOlme, OlmesartanSARS-CoV-2 spike/ACE2 complex blockersSartansTelmi, TelmisartanVal, Valsartan

Identifiers

PMID35432786
PMCPMC8994259
OpenAlexW4224224822

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.