ArticleEuropean journal of psychotraumatology2022
Right inferior frontal gyrus and ventromedial prefrontal activation during response inhibition is implicated in the development of PTSD symptoms.
Article in European journal of psychotraumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Effects of single-session transcranial direct current stimulation on response inhibition in stop-signal task performance: A meta-analysis and systematic review.General psychiatry · 2026Article
- Lower Gyrification of the Ventromedial Prefrontal Cortex in Posttraumatic Stress Disorder: An ENIGMA-PTSD Study.Biological psychiatry global open science · 2026Article
- Target variability and stability of neuroimaging-guided transcranial magnetic stimulation of the amygdala circuitry for posttraumatic stress disorder.Research square · 2026Article
- Biological mechanisms underlying adverse mental health outcome after trauma.European journal of psychotraumatology · 2025Article
- Altered right inferior frontal gyrus-based functional connectivity associated with inhibition through swimming exercise in children with attention deficit hyperactivity disorder.BMC pediatrics · 2025Article
- Inhibitory control impairments underlie associative memory deficits in posttraumatic stress disorder.PloS one · 2025Article
- Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field.Molecular psychiatry · 2024Review
- Sex Differences in Response Inhibition-Related Neural Predictors of Posttraumatic Stress Disorder in Civilians With Recent Trauma.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Defining theNature. Mental health · 2024Article
- Greater Early Posttrauma Activation in the Right Inferior Frontal Gyrus Predicts Recovery From Posttraumatic Stress Disorder Symptoms.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
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Abstract
Background: Inhibition is a critical executive control process and an established neurobiological phenotype of PTSD, yet to our knowledge, no prospective studies have examined this using a contextual cue task that enables measurement of behavioural response and neural activation patterns across proactive and reactive inhibition. Objective: The current longitudinal study utilised functional magnetic resonance imaging (fMRI) to examine whether deficits in proactive and reactive inhibition predicted PTSD symptoms six months after trauma. Method: Twenty-three (65% males) medical patients receiving emergency medical care from a level 1 trauma centre were enrolled in the study and invited for an MRI scan 1-2-months post-trauma. PTSD symptoms were measured using self-report at scan and 6-months post-trauma. A stop-signal anticipation task (SSAT) during an fMRI scan was used to test whether impaired behavioural proactive and reactive inhibition, and reduced activation in right inferior frontal gyrus (rIFG), ventromedial prefrontal cortex (vmPFC), and bilateral hippocampus, were related to PTSD symptoms. We predicted that lower activation levels of vmPFC and rIFG during reactive inhibition and lower activation of hippocampus and rIFG during proactive inhibition would relate to higher 6-month PTSD symptoms. Results: No significant associations were found between behavioural measures and 6-month PTSD. Separate linear regression analyses showed that reduced rIFG activation ( Conclusion: Our findings suggest that impaired rIFG and, to a lesser extent, vmPFC activation during response inhibition may predict the development of PTSD symptoms following acute trauma exposure. Given the small sample size, future replication studies are needed. HIGHLIGHTS: Impaired inhibition may be an important risk factor for the development of PTSD following trauma, with less right inferior frontal gyrus and ventromedial prefrontal cortex activation during response inhibition predicting PTSD development.
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