Evidence map›Paper›PMID 35432723›Full record

ArticleOxidative medicine and cellular longevity2022

Importance of Gedunin in Antagonizing Rheumatoid Arthritis via Activating the Nrf2/ARE Signaling.

Jian-Yu Chen, Xiao-Yun Tian, Wen-Jing Liu, Bao-Kun Wu, Yue-Chan Wu, Ming-Xing Zhu, Jin-Liu, Xian Zhou, Yan-Fang Zheng, Xue-Qin Ma and 1 more

RetractedAbstract readRetracted Publication
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jian-Yu ChenFujian University of Traditional Chinese Medicine, School of Pharmacy, Fuzhou, Fujian 350122, China.
Xiao-Yun TianFujian University of Traditional Chinese Medicine, School of Pharmacy, Fuzhou, Fujian 350122, China.
Wen-Jing LiuFujian University of Traditional Chinese Medicine, School of Pharmacy, Fuzhou, Fujian 350122, China.
Bao-Kun WuFujian University of Traditional Chinese Medicine, School of Pharmacy, Fuzhou, Fujian 350122, China.
Yue-Chan WuLiuHe Township Health Center, No. 63, LiuHe Road, Qi Chun Liu He, Huang Gang 436328, China.
Ming-Xing ZhuFujian University of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
Jin-LiuFujian University of Traditional Chinese Medicine, School of Pharmacy, Fuzhou, Fujian 350122, China.
Xian ZhouNICM Health Research Institute, Western Sydney University, Penrith, NSW, Australia.
Yan-Fang ZhengFujian University of Traditional Chinese Medicine, School of Pharmacy, Fuzhou, Fujian 350122, China.ORCID https://orcid.org/0000-0003-4731-4499
Xue-Qin MaDepartment of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, Ningxia 750004, China.ORCID https://orcid.org/0000-0003-4818-5967
Ming-Qing HuangFujian University of Traditional Chinese Medicine, School of Pharmacy, Fuzhou, Fujian 350122, China.ORCID https://orcid.org/0000-0002-2853-1087

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study assessed the anti-arthritic effect and protection of Gedunin (GDN) on joint tissues and revealed the possible mechanism in suppressing rheumatoid arthritis (RA). Methods: LPS-induced macrophages and TNF- Conclusions: Our study suggested that GDN exhibited strong antagonistic effect on arthritis both

Indexed as

Arthritis, RheumatoidNF-E2-Related Factor 2CytokinesFibroblastsHumansKelch-Like ECH-Associated Protein 1LimoninsLipopolysaccharidesReactive Oxygen SpeciesRNA, MessengerSynovial MembraneTumor Necrosis Factor-alphaCytokinesgeduninKelch-Like ECH-Associated Protein 1LimoninsLipopolysaccharidesNF-E2-Related Factor 2Reactive Oxygen SpeciesRNA, MessengerTumor Necrosis Factor-alpha

Identifiers

PMID35432723
PMCPMC9010203

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.