Evidence map›Paper›PMID 35432496›Full record

ArticleThe journal of venomous animals and toxins including tropical diseases2022

β-micrustoxin (Mlx-9), a PLA

Natália Fernanda Teixeira Dos Santos, Andréia de Souza Imberg, Douglas Oscar Ceolin Mariano, Angelina Cirelli de Moraes, Jessica Andrade-Silva, Cristina Maria Fernandes, Ana Cláudia Sobral, Karina Cristina Giannotti, Wilson M Tatagiba Kuwabara, Daniel Carvalho Pimenta and 3 more

Open access · goldAbstract read
In one paragraph

Article in The journal of venomous animals and toxins including tropical diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Natália Fernanda Teixeira Dos SantosLaboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil.
Andréia de Souza ImbergLaboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil.
Douglas Oscar Ceolin MarianoLaboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, SP, Brazil.ORCID 0000-0001-7296-5475
Angelina Cirelli de MoraesLaboratory of Molecular Biology, Butantan Institute, São Paulo, SP, Brazil.
Jessica Andrade-SilvaDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, SP, Brazil.
Cristina Maria FernandesLaboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil.
Ana Cláudia SobralContaminants Center, Water and Packaging Core, Adolfo Lutz Institute, São Paulo, SP, Brazil.
Karina Cristina GiannottiSpecial Pain and Signaling Laboratory, Butantan Institute, São Paulo, SP, Brazil.
Wilson M Tatagiba KuwabaraDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, SP, Brazil.
Daniel Carvalho PimentaLaboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, SP, Brazil.ORCID 0000-0003-2406-0860
Durvanei Augusto MariaLaboratory of Molecular Biology, Butantan Institute, São Paulo, SP, Brazil.
Maria Regina Lopes SandovalLaboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil.
Solange Castro AfecheLaboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil.ORCID 0000-0001-6195-7859
Instituto Butantan · BRUniversidade de São Paulo · BRInstituto Adolfo Lutz · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Endogenous phospholipases A Methods: β-micrustoxin was characterized biochemically by a proteomic approach. Astrocytes were obtained by dissociation of pineal glands from Wistar rats; glioblastoma tumor cells were purchased from ATCC and Sigma and cultured in DMEM medium. Cell viability was evaluated by MTT assay; cell proliferation and cell cycle phases were analyzed by flow cytometry; p53, p21 and p27 proteins were studied by western blotting and immunocytochemistry. Results: Proteomic analysis revealed fragments on β-micrustoxin that aligned with a PLA Conclusion: These findings indicate that β-micrustoxin from

Indexed as

AstrocytesGlioblastomaMicrurus lemniscatus venomMlx-9p53 proteinPLA2β-micrustoxin

Identifiers

PMID35432496
PMCPMC9008913
OpenAlexW4226147722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.