Evidence map›Paper›PMID 35432373›Full record

ArticleFrontiers in immunology2022

HSV-2-Specific Human Female Reproductive Tract Tissue Resident Memory T Cells Recognize Diverse HSV Antigens.

David M Koelle, Lichun Dong, Lichen Jing, Kerry J Laing, Jia Zhu, Lei Jin, Stacy Selke, Anna Wald, Dana Varon, Meei-Li Huang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. PD-1 Inhibits CD4+ TRM-Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Tissue-resident memory T cells reshapeFrontiers in immunology · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Therapeutic vaccines for herpesviruses.The Journal of clinical investigation · 2024
    Review
  13. Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

David M KoelleDepartment of Medicine, University of Washington, Seattle, WA, United States.
Lichun DongDepartment of Medicine, University of Washington, Seattle, WA, United States.
Lichen JingDepartment of Medicine, University of Washington, Seattle, WA, United States.
Kerry J LaingDepartment of Medicine, University of Washington, Seattle, WA, United States.
Jia ZhuDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
Lei JinDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
Stacy SelkeDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
Anna WaldDepartment of Medicine, University of Washington, Seattle, WA, United States.
Dana VaronDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
Meei-Li HuangDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
Christine JohnstonDepartment of Medicine, University of Washington, Seattle, WA, United States.
Lawrence CoreyDepartment of Medicine, University of Washington, Seattle, WA, United States.
Christine M PosavadDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.
University of Washington · USFred Hutch Cancer Center · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Large Scale T Cell Epitope Discovery: Local and Systemic T cell Response to Herpes Simplex Virus75N93019C00063 · NIAID · UNIVERSITY OF WASHINGTON · PI MYER, TIM · 2019 to 2023
$5.5M
Harnessing Tissue Resident Memory T Cells for Immunotherapy of Herpes Virus InfectionsR01AI134878 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI COREY, LAWRENCE · 2018 to 2022
$3.4M
Modeling of human HSV infection: development of immune-competent 3D skin-on-chip with vascular perfusionR01AI143773 · NIAID · UNIVERSITY OF WASHINGTON · PI ZHU, JIA · 2020 to 2024
$2.7M
CYTOTOXIC T CELL RESPONSES TO HSV IN HIV INFECTIONR01AI042528 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI COREY, LAWRENCE, ZHU, JIA · 1998 to 2016
$2.7M
T Cell Immunity to HSV-2 in Immune Seronegative SubjectsR01AI091701 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI POSAVAD, CHRISTINE M · 2011 to 2015
$1.9M
Innate Resistance to Mucosal HSV Infection in HumansR21AI083418 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI POSAVAD, CHRISTINE M · 2009 to 2010
$415k
NCI NIH HHS P30 CA015704NIAID NIH HHS 75N93019C00063NIAID NIH HHS R01 AI042528NIAID NIH HHS R01 AI091701NIAID NIH HHS R01 AI134878NIAID NIH HHS R01 AI143773NIAID NIH HHS R21 AI083418
6 · The paper itself

Abstract

Antigen-specific T

Indexed as

Herpes GenitalisHerpes SimplexAntigens, ViralFemaleHerpesvirus 2, HumanHumansImmunologic MemoryMemory T CellsPeptidesAntigens, ViralPeptidesCD4CD8dendritic cellepitopefemale reproductive tract immunologyHSV-2

Identifiers

PMID35432373
PMCPMC9009524
OpenAlexW4220907060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.