Evidence map›Paper›PMID 35432348›Full record

ReviewFrontiers in immunology2022

The Impact of Alcohol Use Disorder on Tuberculosis: A Review of the Epidemiology and Potential Immunologic Mechanisms.

Gregory W Wigger, Tara C Bouton, Karen R Jacobson, Sara C Auld, Samantha M Yeligar, Bashar S Staitieh

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 50 citations in OpenAlex.

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  9. Molecular Epidemiology ofMicroorganisms · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gregory W WiggerDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Tara C BoutonSection of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, MA, United States.
Karen R JacobsonSection of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, MA, United States.
Sara C AuldDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Samantha M YeligarDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Bashar S StaitiehDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Emory University · USBoston University · US

Funding

The Role of Alcohol Use in Lung Disease After Treatment for Active TB Disease Among Persons Living with HIVP01AA029541 · NIAAA · BOSTON MEDICAL CENTER · PI SAMET, JEFFREY H. · 2021 to 2025
$7.5M
Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Jeffrey M Collins · 2022 to 2026
$5.8M
The Emory Training Program in Lung HealthT32HL116271 · NHLBI · EMORY UNIVERSITY · PI BROWN, LOU ANN S, GUIDOT, DAVID MARSHALL · 2013 to 2022
$4.2M
The impact of alcohol consumption on TB treatment outcomesR01AI119037 · NIAID · BOSTON MEDICAL CENTER · PI JACOBSON, KAREN R · 2016 to 2020
$3.3M
Alcohol-Induced Mitochondrial Derangements Cause Alveolar Macrophage DysfunctionR01AA026086 · NIAAA · EMORY UNIVERSITY · PI YELIGAR, SAMANTHA M. · 2018 to 2022
$1.8M
Understanding HIV's impact on RR/MDR-TB development and transmission through genomicsK23AI152930 · NIAID · BOSTON MEDICAL CENTER · PI BOUTON, TARA CATHERINE · 2021 to 2025
$1.0M
Impact of HIV infection on early responses to TB exposureK23AI134182 · NIAID · EMORY UNIVERSITY · PI AULD, SARA · 2018 to 2023
$972k
Alcohol inhibits anti-oxidant and immune defenses in the lungK08AA024512 · NIAAA · EMORY UNIVERSITY · PI STAITIEH, BASHAR SAMIH · 2017 to 2021
$957k
NHLBI NIH HHS T32 HL116271NIAAA NIH HHS K08 AA024512NIAAA NIH HHS P01 AA029541NIAAA NIH HHS R01 AA026086NIAID NIH HHS K23 AI134182NIAID NIH HHS K23 AI152930NIAID NIH HHS P30 AI168386NIAID NIH HHS R01 AI119037
6 · The paper itself

Abstract

Globally, an estimated 107 million people have an alcohol use disorder (AUD) leading to 2.8 million premature deaths each year. Tuberculosis (TB) is one of the leading causes of death globally and over 8% of global TB cases are estimated to be attributable to AUD. Social determinants of health such as poverty and undernutrition are often shared among those with AUD and TB and could explain the epidemiologic association between them. However, recent studies suggest that these shared risk factors do not fully account for the increased risk of TB in people with AUD. In fact, AUD has been shown to be an independent risk factor for TB, with a linear increase in the risk for TB with increasing alcohol consumption. While few studies have focused on potential biological mechanisms underlying the link between AUD and TB, substantial overlap exists between the effects of alcohol on lung immunity and the mechanisms exploited by

Indexed as

AlcoholismTuberculosisAlcohol DrinkingEthanolHumansMacrophages, AlveolarMycobacterium tuberculosisEthanolalcoholalcohol use disorder (AUD)alveolar macrophage (AM)innate immunityoxidative stresstuberculosis

Identifiers

PMID35432348
PMCPMC9009367
OpenAlexW4221086850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.