Evidence map›Paper›PMID 35432326›Full record

ReviewFrontiers in immunology2022

Fungal CNS Infections in Africa: The Neuroimmunology of Cryptococcal Meningitis.

Sally H Mohamed, Tinashe K Nyazika, Kenneth Ssebambulidde, Michail S Lionakis, David B Meya, Rebecca A Drummond

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
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  7. Review
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  13. State of the Field: Cytotoxic Immune Cell Responses inJournal of fungi (Basel, Switzerland) · 2024
    Review
  14. Article
  15. Review
  16. Article
  17. Article
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  19. Article
  20. Journal of fungi (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Sally H MohamedInstitute of Immunology & Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Tinashe K NyazikaDepartment of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Kenneth SsebambuliddeCollege of Health Sciences, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Michail S LionakisFungal Pathogenesis Section, Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
David B MeyaCollege of Health Sciences, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Rebecca A DrummondInstitute of Immunology & Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Makerere University · UGUniversity of Birmingham · GBLiverpool School of Tropical Medicine · GBNational Institutes of Health · US

Funding

Immunopathogenesis of Fungal InfectionsZIAAI001175 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LIONAKIS, MICHAIL · 2012 to 2025
$23.9M
Medical Research Council MR/S024611/1Medical Research Council MR/T029137/1
6 · The paper itself

Abstract

Cryptococcal meningitis (CM) is the leading cause of central nervous system (CNS) fungal infections in humans, with the majority of cases reported from the African continent. This is partly due to the high burden of HIV infection in the region and reduced access to standard-of-care including optimal sterilising antifungal drug treatments. As such, CM is responsible for 10-15% of all HIV-related mortality, with a large proportion being preventable. Immunity to the causative agent of CM,

Indexed as

Central Nervous System Fungal InfectionsCryptococcosisCryptococcus neoformansHIV InfectionsMeningitis, CryptococcalAntifungal AgentsHumansAntifungal Agentsastrocytecryptococcal meningitisfungal infectionHAARTmicroglia

Identifiers

PMID35432326
PMCPMC9010970
OpenAlexW4220867259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.