Evidence map›Paper›PMID 35431971›Full record

ArticleFrontiers in pharmacology2022

Conditioned Medium From the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Neuropathic Pain in a Partial Sciatic Nerve Ligation Model.

Yao Liu, Fumiya Kano, Noboru Hashimoto, Linze Xia, Qiao Zhou, Xingmei Feng, Hideharu Hibi, Aya Miyazaki, Tsutomu Iwamoto, Yoshizo Matsuka and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Yao LiuDepartment of Tissue Regeneration, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Fumiya KanoDepartment of Tissue Regeneration, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Noboru HashimotoDepartment of Tissue Regeneration, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Linze XiaDepartment of Tissue Regeneration, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Qiao ZhouDepartment of Stomatology, Affiliated Hospital, Nantong University, Nantong, China.
Xingmei FengDepartment of Stomatology, Affiliated Hospital, Nantong University, Nantong, China.
Hideharu HibiDepartment of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Aya MiyazakiPediatric Dentistry, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Tsutomu IwamotoPediatric Dentistry, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Yoshizo MatsukaDepartment of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Zhijun ZhangDepartment of Human Anatomy, School of Medicine, Nantong University, Nantong, China.
Eiji TanakaOrthodontics and Dentofacial Orthopedics, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Akihito YamamotoDepartment of Tissue Regeneration, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Tokushima University · JPAffiliated Hospital of Nantong University · CNNagoya University · JPNantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In neuropathic pain (NP), injury or diseases of the somatosensory system often result in highly debilitating chronic pain. Currently, there is no effective drug for the complete and definitive treatment of NP. We investigated the therapeutic potential of conditioned medium (CM) derived from stem cells from human exfoliated deciduous teeth (SHED-CM) against NP using a mouse partial sciatic nerve ligation (PSL) model. Abnormal pain sensation, such as tactile allodynia and hyperalgesia, can be caused by PSL. In the behavioral test, intravenous administration of SHED-CM greatly improved the PSL-induced hypersensitivity. We found that treatment with SHED-CM resulted in the recruitment of M2 macrophages in the injured sciatic nerve and ipsilateral L4/L5 dorsal root ganglion and suppressed microglial activation in the spinal cord. Notably, specific depletion of the anti-inflammatory M2 macrophages by mannosylated-Clodrosome markedly reduced the antinociceptive effect of SHED-CM. Intravenous administration of CM from M2 induced by SHED-CM (M2-CM) ameliorated the PSL-induced hypersensitivity. We found that M2-CM directly suppressed the expression of nociceptive receptors as well as proinflammatory mediators in Schwann cells. Taken together, our data suggest that SHED-CM ameliorates NP through the induction of the analgesic anti-inflammatory M2 macrophages. Thus, SHED-CM may be a novel therapeutic candidate for NP.

Indexed as

conditioned mediumdental pulp stem cellsmacrophageMCP-1neuropathic painsiglec-9

Identifiers

PMID35431971
PMCPMC9009354
OpenAlexW4225810146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.