Evidence map›Paper›PMID 35431888›Full record

ArticleFrontiers in aging neuroscience2022

Systemic-Immune-Inflammation Index as a Promising Biomarker for Predicting Perioperative Ischemic Stroke in Older Patients Who Underwent Non-cardiac Surgery.

Faqiang Zhang, Mu Niu, Long Wang, Yanhong Liu, Likai Shi, Jiangbei Cao, Weidong Mi, Yulong Ma, Jing Liu

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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  14. Prediction of Ecchymosis and Edema after Rhinoplasty: Changes in Perioperative Inflammation Indixes.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Faqiang ZhangAnesthesia and Operation Center, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Mu NiuDepartment of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, China.
Long WangDepartment of Pain Medicine, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Yanhong LiuAnesthesia and Operation Center, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Likai ShiAnesthesia and Operation Center, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Jiangbei CaoAnesthesia and Operation Center, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Weidong MiAnesthesia and Operation Center, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Yulong MaAnesthesia and Operation Center, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Jing LiuAnesthesia and Operation Center, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Chinese PLA General Hospital · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to investigate the clinical prognostic values of the preoperative systemic-immune-inflammation index (SII) in older patients undergoing non-cardiac surgery, using perioperative ischemic stroke as the primary outcome. Methods: This retrospective cohort study included older patients who underwent non-cardiac surgery between January 2008 and August 2019. The patients were divided into SII < 583 and SII ≥ 583 group according to the optimal SII cut-off value. The outcome of interest was ischemic stroke within 30 days after surgery. Primary, sensitivity, and subgroup analyses were performed to confirm that preoperative SII qualifies as a promising, independent prognostic indicator. Propensity score matching (PSM) analysis was further applied to address the potential residual confounding effect of covariates to examine the robustness of our results. Results: Among the 40,670 included patients with a median age of 70 years (interquartile range: 67, 74), 237 (0.58%) experienced an ischemic stroke within 30 days after surgery. SII ≥ 583 was associated with an increased risk of perioperative ischemic stroke in multivariate regression analysis [odds ratio (OR), 1.843; 95% confidence interval (CI), 1.369-2.480; Conclusion: Preoperative SII, which includes neutrophil, platelet, and lymphocyte counts obtained from routine blood analysis, was a potential prognostic biomarker for predicting perioperative ischemic stroke after non-cardiac surgery in elderly older patients. An elevated SII, based on an optimal cut-off value of 583, was an independent risk factor for perioperative ischemic stroke.

Indexed as

biomarkerinflammationolder patientsperioperative strokepostoperative complicationsystemic-immune-inflammation index (SII)

Identifiers

PMID35431888
PMCPMC9010030
OpenAlexW4220716512

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.