Evidence map›Paper›PMID 35431857›Full record

ArticleCase reports in oncology

Hodgkin Lymphoma on Hemodialysis Successfully Treated with Extended Courses of Brentuximab Vedotin.

Ayana Uchimura, Hajime Yasuda, Jun Ando, Yasunori Ota, Makoto Sasaki, Tomoiku Takaku, Yutaka Tsukune, Miyuki Tsutsui, Yoko Edahiro, Naoki Watanabe and 3 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Ayana UchimuraDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Hajime YasudaDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Jun AndoDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Yasunori OtaDepartment of Pathology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Makoto SasakiDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Tomoiku TakakuDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Yutaka TsukuneDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Miyuki TsutsuiDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Yoko EdahiroDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Naoki WatanabeDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Tomonori OchiaiDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Norio KomatsuDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Miki AndoDepartment of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Juntendo University · JPUniversity of Tokyo Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy for hemodialysis (HD) patients is a challenging situation because HD patients are generally frail, and the pharmacokinetics and pharmacodynamics of most chemotherapeutics in HD patients are unknown. We report a classical Hodgkin lymphoma (cHL) patient successfully treated with 34 courses of brentuximab vedotin (BV) monotherapy, of which 30 courses were carried out during HD. Although grade 2 peripheral sensory neuropathy and one occasion of febrile neutropenia were observed, treatment was well-tolerated overall and effective. This is the first report of successful BV administration in a cHL patient on HD, and also the first to report efficacy and safety of extended courses of BV in an HD patient. Treatment options for cHL in the HD patient are limited, and extended courses of BV monotherapy may be an optimal treatment approach for some patients.

Indexed as

Anti-CD30 therapyCastleman diseaseDoxorubicin, bleomycin, vinblastine, and dacarbazineEnd-stage renal diseaseMonomethyl auristatin E

Identifiers

PMID35431857
PMCPMC8958608
OpenAlexW4220874055

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.