Evidence map›Paper›PMID 35431088›Full record

ArticleDental materials : official publication of the Academy of Dental Materials2022

Dentin collagen denaturation status assessed by collagen hybridizing peptide and its effect on bio-stabilization of proanthocyanidins.

Rong Wang, Saleha Nisar, Zachary Vogel, Hang Liu, Yong Wang

Open access · greenAbstract read
In one paragraph

Article in Dental materials : official publication of the Academy of Dental Materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Bond preservation in caries-affected dentin restored with acrylamide-based adhesives.Dental materials : official publication of the Academy of Dental Materials · 2025
    Article
  3. Article
  4. Article
  5. Multi-acrylamides improve bond stability through collagen reinforcement under physiological conditions.Dental materials : official publication of the Academy of Dental Materials · 2024
    Article
  6. Article
  7. Article
  8. Peptides in Dentistry: A Scoping Review.Bioengineering (Basel, Switzerland) · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rong WangSchool of Dentistry, University of Missouri - Kansas City, Kansas City, MO 64108, USA.
Saleha NisarSchool of Dentistry, University of Missouri - Kansas City, Kansas City, MO 64108, USA.
Zachary VogelSchool of Dentistry, University of Missouri - Kansas City, Kansas City, MO 64108, USA.
Hang LiuSchool of Dentistry, University of Missouri - Kansas City, Kansas City, MO 64108, USA.
Yong WangSchool of Dentistry, University of Missouri - Kansas City, Kansas City, MO 64108, USA. Electronic address: wangyo@umkc.edu.
University of Missouri–Kansas City · US

Funding

Texas Tech Center for Translational Research and Rural Health - Research Capacity CoreU54MD020892 · NIMHD · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI Jonathan Singer · 2026 to 2026
$10.0M
Development of multifunctional resins for robust dentin bondingR01DE027049 · NIDCR · UNIVERSITY OF MISSOURI KANSAS CITY · PI WANG, YONG · 2018 to 2022
$1.8M
NIDCR NIH HHS R01 DE027049NIMHD NIH HHS U54 MD020892
6 · The paper itself

Abstract

objectiveTo assess dentin collagen denaturation from phosphoric acid and enzyme treatments using collagen hybridizing peptide (CHP) and to investigate the effect of collagen denaturation on bio-stabilization promoted by proanthocyanidins (PA).

methodsHuman molars were sectioned into 7-µm-thick dentin films, demineralized, and assigned to six groups: control with/without PA modification, H

resultsFTIR showed collagen secondary structural changes after denaturation treatments and confirmed the incorporation and cross-linking of PA in control and treated collagen. F-CHP staining indicated high-degree, medium-degree, and low-degree collagen denaturation from H SIGNIFICANCE: A molecular method CHP is introduced as a sensitive technique to quantitate dentin collagen denaturation for the first time. PA modification is shown to effectively stabilize denatured collagen against collagenase digestion, with the stabilization effect negatively associated with the collagen denaturation degree.

Indexed as

ProanthocyanidinsCollagenCollagenasesDentinHumansHydroxyprolinePeptidesWeight LossCollagenCollagenasesHydroxyprolinePeptidesProanthocyanidinsCollagen bio-stabilizationCollagen hybridizing peptideCross-linkingDentin collagen denaturationFTIRHydroxyproline assayProanthocyanidinsWeight loss

Identifiers

PMID35431088
PMCPMC9060396
OpenAlexW4223947416

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.