Evidence map›Paper›PMID 35431034›Full record

ArticleThe Journal of thoracic and cardiovascular surgery2023

Early posthospitalization recovery after extracorporeal membrane oxygenation in survivors of COVID-19.

Lauren J Taylor, Sarah E Jolley, Chintan Ramani, Kirby P Mayer, Eric W Etchill, Matthew F Mart, Shoaib Fakhri, Skyler Peterson, Kathryn Colborn, Carla M Sevin and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of thoracic and cardiovascular surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Outcomes of venovenous-extracorporeal membrane oxygenation bridging in lung transplant recipients with panel reactive antibody positivity.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Lauren J TaylorDivision of Cardiothoracic Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colo.
Sarah E JolleyDivision of Pulmonary Sciences and Critical Care, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colo.
Chintan RamaniDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, Va.
Kirby P MayerDepartment of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Ky.
Eric W EtchillDivision of Cardiothoracic Surgery, Department of Surgery, Johns Hopkins University, Baltimore, Md.
Matthew F MartDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, Tenn.
Shoaib FakhriDivision of Pulmonary Sciences and Critical Care, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colo.
Skyler PetersonDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colo.
Kathryn ColbornDivision of Cardiothoracic Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colo.
Carla M SevinDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, Tenn.
Alexandra KadlDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, Va.
Kyle EnfieldDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, Va.
Glenn J R WhitmanDivision of Cardiothoracic Surgery, Department of Surgery, Johns Hopkins University, Baltimore, Md.
Joseph B ZwischenbergerDivision of Cardiothoracic Surgery, Department of Surgery, College of Medicine, University of Kentucky, Lexington, Ky.
Jessica Y RoveDivision of Cardiothoracic Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colo. Electronic address: Jessica.Rove@cuanschutz.edu.
ORACLE group

Funding

Cellular and Physical Function Outcomes Leading to Failed Muscle Recovery After Critical IllnessK23AR079583 · NIAMS · UNIVERSITY OF KENTUCKY · PI Kirby P Mayer · 2022 to 2026
$744k
Prevalence of ICU-Acquired Myopathy in Patients with Alcohol Use DisordersK23AA026315 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI JOLLEY, SARAH E · 2018 to 2022
$696k
NIAAA NIH HHS K23 AA026315NIAMS NIH HHS K23 AR079583NIMHD NIH HHS L32 MD017732
6 · The paper itself

Abstract

objectiveWe sought to determine the influence of venovenous extracorporeal membrane oxygenation (ECMO) on outcomes of mechanically ventilated patients with COVID-19 during the first 120 days after hospital discharge.

methodsFive academic centers conducted a retrospective analysis of mechanically ventilated patients with COVID-19 admitted during March through May 2020. Survivors had access to a multidisciplinary postintensive care recovery clinic. Physical, psychological, and cognitive deficits were measured using validated instruments and compared based on ECMO status.

resultsTwo hundred sixty two mechanically ventilated patients were compared with 46 patients cannulated for venovenous ECMO. Patients receiving ECMO were younger and traveled farther but there was no significant difference in gender, race, or body mass index. ECMO patients were mechanically ventilated for longer durations (median, 26 days [interquartile range, 19.5-41 days] vs 13 days [interquartile range, 7-20 days]) and were more likely to receive inhaled pulmonary vasodilators, neuromuscular blockade, investigational COVID-19 therapies, blood transfusions, and inotropes. Patients receiving ECMO experienced greater bleeding and clotting events (P < .01). However, survival at discharge was similar (69.6% vs 70.6%). Of the 217 survivors, 65.0% had documented follow-up within 120 days. Overall, 95.5% were residing at home, 25.7% had returned to work or usual activity, and 23.1% were still using supplemental oxygen; these rates did not differ significantly based on ECMO status. Rates of physical, psychological, and cognitive deficits were similar.

conclusionsOur data suggest that COVID-19 survivors experience significant physical, psychological, and cognitive deficits following intensive care unit admission. Despite a more complex critical illness course, longer average duration of mechanical ventilation, and longer average length of stay, patients treated with venovenous ECMO had similar survival at discharge and outcomes within 120 days of discharge.

Indexed as

COVID-19Extracorporeal Membrane OxygenationHumansIntensive Care UnitsRetrospective StudiesSurvivorscoronaviruscritical illnessECMOlong-term outcomes

Identifiers

PMID35431034
PMCPMC8920082

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.