ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2022
Socioeconomic status, individual behaviors and risk for mental disorders: A Mendelian randomization study.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Nutritional Management of Schizophrenia: Gut-Brain Axis Mechanisms and Dietary Interventions.Molecular neurobiology · 2026Review
- A community screening tool for neuropsychiatric symptoms in the elderly: integrating cortisol, microbiome, and social factors with machine learning.Translational psychiatry · 2026Observational
- Rheumatoid arthritis and risk of lung diseases in East Asians and Europeans: Evidence from a Mendelian randomization study.SAGE open medicine · 2026Article
- Constipation and Psychiatric Disorders: A Bidirectional Mendelian Randomization Study.Combinatorial chemistry & high throughput screening · 2026Article
- Genetic insights into blood urea nitrogen as a risk factor for coronary artery disease: a Mendelian randomization study in East Asians.Renal failure · 2025Article
- Socioeconomic status, depressive symptoms and cardiometabolic kidney syndrome: an analysis based on national representative data.BMC public health · 2025Article
- Factors Influencing Symptoms of Depression, Anxiety and Stress in Patients With Haemophilia.Haemophilia : the official journal of the World Federation of Hemophilia · 2025Article
- Bayesian causal graphical model for joint Mendelian randomization analysis of multiple exposures and outcomes.American journal of human genetics · 2025Article
- Exploring the silent connection: unveiling the intricate relationship between gastroesophageal reflux disease and sleep apnea syndrome.Human genomics · 2025Article
- Causal associations between iron levels in subcortical brain regions and psychiatric disorders: a Mendelian randomization study.Translational psychiatry · 2025Article
- Causal Relationship Between Socioeconomic Inequality and Hormone-Related Gynecologic Diseases: A Two-Sample, Two-Step Mendelian Randomization Study.International journal of women's health · 2025Article
- Investigating the Mediating Role of Mental Disorders in the Relationship Between Early Sexual Intercourse and Intentional Self-Harm: A Two-Step and Multivariable Mendelian Randomization Study.Brain and behavior · 2024Article
- Causal relationship between major depressive disorder, anxiety disorder and constipation: a two-sample Mendelian randomization study.BMC gastroenterology · 2024Article
- Neighborhood socioeconomic status and postpartum depression among commercial health insurance enrollees: a retrospective cohort study.BMC pregnancy and childbirth · 2024Article
- Identification of novel protein biomarkers and therapeutic targets for ankylosing spondylitis using human circulating plasma proteomics and genome analysis.Analytical and bioanalytical chemistry · 2024Article
- Identification of immune traits associated with neurodevelopmental disorders by two-sample Mendelian randomization analysis.BMC psychiatry · 2024Article
- Associations between reproductive factors and the prevalence of depression: findings from the National Health and Nutrition Examination Survey (NHANES) 2005-2018.BMC public health · 2024Article
- Allopurinol is Associated with an Increased Risk of Cerebral Infarction: A Two-Sample Mendelian Randomization Study.ACS omega · 2024Article
- Causal Relationships between Lipid-Lowering Drug Target and Aortic Disease and Calcific Aortic Valve Stenosis: A Two-Sample Mendelian Randomization.Reviews in cardiovascular medicine · 2024Article
- Development of a harmonized sociodemographic and clinical questionnaire for mental health research: A Delphi-method-based consensus recommendation.The Australian and New Zealand journal of psychiatry · 2024Review
Corrections and comments
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7 authors.
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Abstract
backgroundThere is increasing attention on the association of socioeconomic status and individual behaviors (SES/IB) with mental health. However, the impacts of SES/IB on mental disorders are still unclear. To provide evidence for establishing feasible strategies on disease screening and prevention, we implemented Mendelian randomization (MR) design to appraise causality between SES/IB and mental disorders.
methodsWe conducted a two-sample MR study to assess the causal effects of SES and IB (dietary habits, habitual physical activity, smoking behaviors, drinking behaviors, sleeping behaviors, leisure sedentary behaviors, risky behaviors, and reproductive behaviors) on three mental disorders, including bipolar disorder, major depressive disorder and schizophrenia. A series of filtering steps were taken to select eligible genetic instruments robustly associated with each of the traits. Inverse variance weighted was used for primary analysis, with alternative MR methods including MR-Egger, weighted median, and weighted mode estimate. Complementary methods were further used to detect pleiotropic bias.
resultsAfter Bonferroni correction and rigorous quality control, we identified that SES (educational attainment), smoking behaviors (smoking initiation, number of cigarettes per day), risky behaviors (adventurousness, number of sexual partners, automobile speeding propensity) and reproductive behavior (age at first birth) were causally associated with at least one of the mental disorders.
conclusionsMR study provides robust evidence that SES/IB play broad impacts on mental disorders.
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