ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2022
How HLA diversity is apportioned: influence of selection and relevance to transplantation.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review reveals that African children of 15-17 years demonstrate low hepatitis B vaccine seroprotection rates.Scientific reports · 2023Pooled it
- Targeting Amastigote and Trypomastigote Phases: Multi-Epitope Vaccine Strategy Against Trypanosoma cruzi.Biotechnology and applied biochemistry · 2026Article
- Article
- Anti-HLA antibodies in lung transplantation: diagnostic pitfalls and future directions.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Europeans and Americans of European origin show differences between their biological pathways related to the major histocompatibility complex.Scientific reports · 2024Article
- Genetic history of Cambridgeshire before and after the Black Death.Science advances · 2024Article
- Combined imputation of HLA genotype and self-identified race leads to better donor-recipient matching.Human immunology · 2023Article
- Host Transcriptional Regulatory Genes and Microbiome Networks Crosstalk through Immune Receptors Establishing Normal and Tumor Multiomics Metafirm of the Oral-Gut-Lung Axis.International journal of molecular sciences · 2023Review
- Inferring Balancing Selection From Genome-Scale Data.Genome biology and evolution · 2023Review
- [Molecular biology in a blood bank].Revista medica del Instituto Mexicano del Seguro Social · 2023Review
- Review
- The background and legacy of Lewontin's apportionment of human genetic diversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Celebrating 50 years since Lewontin's apportionment of human diversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Mathematical constraints onPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In his 1972 paper 'The apportionment of human diversity', Lewontin showed that, when averaged over loci, genetic diversity is predominantly attributable to differences among individuals within populations. However, selection can alter the apportionment of diversity of specific genes or genomic regions. We examine genetic diversity at the human leucocyte antigen (HLA) loci, located within the major histocompatibility complex (MHC) region. HLA genes code for proteins that are critical to adaptive immunity and are well-documented targets of balancing selection. The single-nucleotide polymorphisms (SNPs) within HLA genes show strong signatures of balancing selection on large timescales and are broadly shared among populations, displaying low
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