Evidence map›Paper›PMID 35430876›Full record

ArticleCirculation research2022

Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self.

Roshni Roy Chowdhury, Jessica D'Addabbo, Xianxi Huang, Stefan Veizades, Koki Sasagawa, David M Louis, Paul Cheng, Jan Sokol, Annie Jensen, Alexandria Tso and 20 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Endothelial Elavl1 Is Required for CD8 T-Cell Persistence in Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Article
  9. Endothelial Elavl1 Fine-Tunes Immune Responses in Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Article
  10. Review
  11. CD8Nature reviews. Cardiology · 2026
    Review
  12. Article
  13. Review
  14. Targeting Arterial Dysfunction in Cardiovascular Disease Using Stem Cell-Based Therapies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  15. Cytotoxic CD4Signal transduction and targeted therapy · 2026
    Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. ApoB-specific CD4Frontiers in immunology · 2026
    Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 8 institutions in 4 countries.

Roshni Roy Chowdhury *Department of Microbiology and Immunology (R.R.C., Y.-H.C., M.M.D.), Stanford University, Stanford, CA, USA.
Jessica D'Addabbo *Department of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
Xianxi Huang *Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Guangdong, China (X.H.).ORCID 0000-0001-5978-5031
Stefan VeizadesDepartment of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
Koki SasagawaDepartment of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
David M LouisInstitute for Immunity, Transplantation and Infection (D.M.L., A.J., A.T., V.S., B.S.W., A.N.N., P.K.N., M.M.D.), Stanford University, Stanford, CA, USA.ORCID 0000-0002-6845-5437
Paul ChengDepartment of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
Jan SokolDepartment of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
Annie JensenDepartment of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
Alexandria TsoDepartment of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.ORCID 0000-0001-5949-7718
Vishnu ShankarInstitute for Immunity, Transplantation and Infection (D.M.L., A.J., A.T., V.S., B.S.W., A.N.N., P.K.N., M.M.D.), Stanford University, Stanford, CA, USA.
Ben Shogo WendelInstitute for Immunity, Transplantation and Infection (D.M.L., A.J., A.T., V.S., B.S.W., A.N.N., P.K.N., M.M.D.), Stanford University, Stanford, CA, USA.ORCID 0000-0001-6896-3354
Isaac BakermanDepartment of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
Grace LiangDepartment of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
Tiffany KoyanoDepartment of Cardiothoracic Surgery (T.K., R.F., J.B., Y.J.W.), Stanford University, Stanford, CA, USA.
Robyn FongDepartment of Cardiothoracic Surgery (T.K., R.F., J.B., Y.J.W.), Stanford University, Stanford, CA, USA.
Allison N NauInstitute for Immunity, Transplantation and Infection (D.M.L., A.J., A.T., V.S., B.S.W., A.N.N., P.K.N., M.M.D.), Stanford University, Stanford, CA, USA.ORCID 0000-0003-2001-2431
Herra AhmadDepartment of Pathology (H.A., J.G., S.J.), Stanford University, Stanford, CA, USA.ORCID 0000-0002-7645-9067
Jayakrishnan GopakumarDepartment of Pathology (H.A., J.G., S.J.), Stanford University, Stanford, CA, USA.ORCID 0000-0003-3895-8188
Robert WirkaDepartment of Medicine and Cell Biology and Physiology, and McAllister Heart Institute, University of North Carolina-Chapel Hill, NC (R.W.).
Andrew S LeeInstitute for Cancer Research, Shenzhen Bay Labs, China (A.S.L.).
Jack BoydDepartment of Cardiothoracic Surgery (T.K., R.F., J.B., Y.J.W.), Stanford University, Stanford, CA, USA.
Y Joseph WooDepartment of Cardiothoracic Surgery (T.K., R.F., J.B., Y.J.W.), Stanford University, Stanford, CA, USA.ORCID 0000-0002-2506-492X
Thomas QuertermousDepartment of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.ORCID 0000-0002-7645-9067
Gunsagar Singh GulatiInstitute for Stem Cell Biology and Regenerative Medicine (G.S.G., C.C.), Stanford University, Stanford, CA, USA.ORCID 0000-0002-7645-9067
Siddhartha JaiswalDepartment of Pathology (H.A., J.G., S.J.), Stanford University, Stanford, CA, USA.ORCID 0000-0002-9597-0477
Yueh-Hsiu ChienDepartment of Microbiology and Immunology (R.R.C., Y.-H.C., M.M.D.), Stanford University, Stanford, CA, USA.
Charles Kwok Fai ChanStanford Cardiovascular Institute (S.V., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., C.K.F.C., P.K.N.), Stanford University, Stanford, CA, USA.
Mark M DavisDepartment of Microbiology and Immunology (R.R.C., Y.-H.C., M.M.D.), Stanford University, Stanford, CA, USA.
Patricia K NguyenDepartment of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.ORCID 0000-0001-7170-9787
Stanford University · USCardiovascular Institute of the South · USHoward Hughes Medical Institute · USInstitute for Stem Cell Biology and Regenerative Medicine · INShantou University · CNShenzhen Bay Laboratory · CNUniversity of Chicago · USUniversity of North Carolina at Chapel Hill · US

Funding

The effects of immune-age on immune-response and the molecular mechanisms which drive itP01AI153559 · NIAID · STANFORD UNIVERSITY · PI DAVIS, MARK MORRIS · 2021 to 2025
$17.8M
Clonal hematopoiesis in human aging and diseaseDP2HL157540 · NHLBI · STANFORD UNIVERSITY · PI JAISWAL, SIDDHARTHA · 2020 to 2020
$2.4M
Multimodality Molecular Imaging of Stem Cell Therapy for Ischemic CardiomyopathyR01HL134830 · NHLBI · STANFORD UNIVERSITY · PI NGUYEN, PATRICIA KIM PHUONG · 2017 to 2021
$2.1M
The Contribution of T cells to the Pathogenesis of Atherosclerosis in Older AdultsR03AG060182 · NIA · STANFORD UNIVERSITY · PI NGUYEN, PATRICIA KIM PHUONG · 2018 to 2019
$236k
The molecular mechanisms of SMAD3-mediated coronary disease riskF32HL143847 · NHLBI · STANFORD UNIVERSITY · PI CHENG, PAUL PO SHENG · 2018 to 2019
$114k
Howard Hughes Medical InstituteNHLBI NIH HHS DP2 HL157540NHLBI NIH HHS F32 HL143847NHLBI NIH HHS R01 HL134830NIAID NIH HHS P01 AI153559NIA NIH HHS R03 AG060182
6 · The paper itself

Abstract

backgroundCoronary artery disease is an incurable, life-threatening disease that was once considered primarily a disorder of lipid deposition. Coronary artery disease is now also characterized by chronic inflammation' notable for the buildup of atherosclerotic plaques containing immune cells in various states of activation and differentiation. Understanding how these immune cells contribute to disease progression may lead to the development of novel therapeutic strategies.

methodsWe used single-cell technology and in vitro assays to interrogate the immune microenvironment of human coronary atherosclerotic plaque at different stages of maturity.

resultsIn addition to macrophages, we found a high proportion of αβ T cells in the coronary plaques. Most of these T cells lack high expression of

conclusionsTaken together, these findings demonstrate that plaque T cells are clonally expanded potentially by antigen engagement, are potentially reactive to self-epitopes, and may interact with smooth muscle cells and macrophages in the plaque microenvironment.

Indexed as

Coronary Artery DiseasePlaque, AtheroscleroticT-LymphocytesAntigensClone CellsEndothelial CellsEpitopesHLA-DR alpha-ChainsHumansLymphocyte ActivationAntigensEpitopesHLA-DR alpha-Chainsatherosclerosiscoronary artery diseaseendothelial cellshumansplaque, atheroscleroticT-lymphocytes

Identifiers

PMID35430876
PMCPMC9286288
OpenAlexW4224077625

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.