Evidence map›Paper›PMID 35430875›Full record

ArticleHypertension (Dallas, Tex. : 1979)2022

Type 1 Angiotensin Receptors on CD11c-Expressing Cells Protect Against Hypertension by Regulating Dendritic Cell-Mediated T Cell Activation.

Xiaohan Lu, Jiandong Zhang, Yi Wen, Jiafa Ren, Robert Griffiths, Nathan P Rudemiller, Shintaro Ide, Tomokazu Souma, Steven D Crowley

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Gut neuropeptide involvement in Parkinson's disease.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiaohan LuDivision of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, NC (X.L., Y.W., J.R., R.G., N.P.R., S.I., T.S., S,D.C.).
Jiandong ZhangDivision of Cardiology, Department of Medicine, University of North Carolina at Chapel Hill (J.Z.).
Yi WenDivision of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, NC (X.L., Y.W., J.R., R.G., N.P.R., S.I., T.S., S,D.C.).
Jiafa RenDivision of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, NC (X.L., Y.W., J.R., R.G., N.P.R., S.I., T.S., S,D.C.).
Robert GriffithsDivision of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, NC (X.L., Y.W., J.R., R.G., N.P.R., S.I., T.S., S,D.C.).
Nathan P RudemillerDivision of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, NC (X.L., Y.W., J.R., R.G., N.P.R., S.I., T.S., S,D.C.).ORCID 0000-0001-9315-3169
Shintaro IdeDivision of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, NC (X.L., Y.W., J.R., R.G., N.P.R., S.I., T.S., S,D.C.).ORCID 0000-0002-9301-211X
Tomokazu SoumaDivision of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, NC (X.L., Y.W., J.R., R.G., N.P.R., S.I., T.S., S,D.C.).ORCID 0000-0002-3285-8613
Steven D CrowleyDivision of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, NC (X.L., Y.W., J.R., R.G., N.P.R., S.I., T.S., S,D.C.).ORCID 0000-0002-1838-0561
Duke University · USUniversity of North Carolina at Chapel Hill · US

Funding

Role of Dendritic Cell-mediated T Cell Activation in Salt-sensitive HypertensionR01HL128355 · NHLBI · DUKE UNIVERSITY · PI CROWLEY, STEVEN D · 2016 to 2019
$1.9M
The interleukin-1 receptor regulates crosstalk between myeloid and renal tubular cells in hypertensionR01DK118019 · NIDDK · DUKE UNIVERSITY · PI CROWLEY, STEVEN D · 2019 to 2022
$1.7M
The role of the M1 macrophage response in the progression of chronic kidney diseaseI01BX000893 · VA · DURHAM VA MEDICAL CENTER · PI Steven D Crowley · 2012 to 2026
–
BLRD VA I01 BX000893NHLBI NIH HHS R01 HL128355NIDDK NIH HHS R01 DK118019
6 · The paper itself

Abstract

backgroundType 1 angiotensin (AT

methodsMice lacking the dominant murine AT

resultsDC AT1aR KO mice had exaggerated hypertensive responses to chronic Ang II infusion with enhanced renal accumulation of effector memory T cells and CD40

conclusionsFollowing activation of the renin angiotensin system, AT1aR stimulation on DCs suppresses renal DC maturation and T cell activation with consequent protection from sodium retention and blood pressure elevation.

Indexed as

HypertensionReceptor, Angiotensin, Type 1Angiotensin IIAnimalsDendritic CellsMiceMice, Inbred C57BLMice, KnockoutReceptors, CCR7SodiumT-LymphocytesAngiotensin IIReceptor, Angiotensin, Type 1Receptors, CCR7SodiumAT1aRdendritic cellhypertensionsodium transportersT cells

Identifiers

PMID35430875
PMCPMC9098690
OpenAlexW4224288328

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.