ArticleJournal of clinical pathology1986
Immunolocalization of cathepsin D in normal and neoplastic human tissues.
Article in Journal of clinical pathology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- Pooled it
- Structural Congeners of Izenamides Responsible for Cathepsin D Inhibition: Insights from Synthesis-Derived Elucidation.Marine drugs · 2023Article
- High Expression of the Lysosomal Protease Cathepsin D Confers Better Prognosis in Neuroblastoma Patients by Contrasting EGF-Induced Neuroblastoma Cell Growth.International journal of molecular sciences · 2022Article
- Development of new in vitro models of lung protease activity for investigating stability of inhaled biological therapies and drug delivery systems.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2020Article
- Cathepsin D deficiency delays central nervous system myelination by inhibiting proteolipid protein trafficking from late endosome/lysosome to plasma membrane.Experimental & molecular medicine · 2018Article
- Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors.Biological chemistry · 2016Article
- Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD.Journal of the American Society of Nephrology : JASN · 2016Article
- Two Faces of Cathepsin D: Physiological Guardian Angel and Pathological Demon.Biology and medicine (Aligarh) · 2014Article
- Decreased immunoreactivities of neocortical AMPA receptor subunits correlate with motor disability in Lewy body dementias.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme.Molecules (Basel, Switzerland) · 2012Article
- Imaging gene delivery in a mouse model of congenital neuronal ceroid lipofuscinosis.Gene therapy · 2011Article
- The expression of E-cadherin and cathepsin-D in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma: A comparative analysis between immunohistochemistry and routine histopathology.Journal of oral and maxillofacial pathology : JOMFP · 2011Article
- A novel approach for characterization of cathepsin D protease and its effect on tau and β-amyloid proteins.Neurochemical research · 2011Article
- Procathepsin D and cancer: From molecular biology to clinical applications.World journal of clinical oncology · 2010Article
- Cathepsin D--many functions of one aspartic protease.Critical reviews in oncology/hematology · 2008Review
- Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Possible role of procathepsin D in human cancer.Folia microbiologica · 2005Review
- Renin and angiotensinogen expression and functions in growth and apoptosis of human glioblastoma.British journal of cancer · 2004Article
- Cathepsin D expression levels in nongynecological solid tumors: clinical and therapeutic implications.Clinical & experimental metastasis · 2004Review
- Procathepsin D in breast cancer: what do we know? Effects of ribozymes and other inhibitors.Cancer gene therapy · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aspartic proteinase cathepsin D was purified from human spleen and localised in various formalin fixed paraffin embedded human tissues using the peroxidase-antiperoxidase (PAP) technique. Cathepsin D was shown not only in macrophages but also in other connective tissue cells, and in epithelium. It was present in spleen (littoral cells and cells within Malpighian bodies), liver (hepatocytes and Kupffer cells), lung (alveolar macrophages and bronchial epithelium), brain (neurones), lymph nodes (histiocytes in germinal centres, sinusoid lining cells) and stomach (parietal and mucous neck cells). Cathepsin D was also found in carcinomas of bronchus, stomach, colon, kidney, breast, ovary, bladder and pancreas, both in neoplastic epithelium and in stromal cells, but was seldom present in connective tissue neoplasms. A group of malignant lymphomas also contained the enzyme within scattered cells. The distribution of cathepsin D seems to be much wider than that of the structurally related aspartic proteinases pepsin, gastricsin, and renin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.