Evidence map›Paper›PMID 35430620›Full record

ArticleScientific reports2022

Black-necked spitting cobra (Naja nigricollis) phospholipases A

Andrea Martos-Esteban, Olivia J S Macleod, Isabella Maudlin, Konstantinos Kalogeropoulos, Jonas A Jürgensen, Mark Carrington, Andreas H Laustsen

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Andrea Martos-EstebanDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK.
Olivia J S MacleodDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK.
Isabella MaudlinDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK.
Konstantinos KalogeropoulosDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Jonas A JürgensenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Mark CarringtonDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK.
Andreas H LaustsenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. ahola@bio.dtu.dk.
University of Cambridge · GBTechnical University of Denmark · DK

Funding

Wellcome TrustWellcome Trust 217138/Z/19/Z
6 · The paper itself

Abstract

African trypanosomes, such as Trypanosoma brucei, are flagellated protozoa which proliferate in mammals and cause a variety of diseases in people and animals. In a mammalian host, the external face of the African trypanosome plasma membrane is covered by a densely packed coat formed of variant surface glycoprotein (VSG), which counteracts the host's adaptive immune response by antigenic variation. The VSG is attached to the external face of the plasma membrane by covalent attachment of the C-terminus to glycosylphosphatidylinositol. As the trypanosome grows, newly synthesised VSG is added to the plasma membrane by vesicle fusion to the flagellar pocket, the sole location of exo- and endocytosis. Snake venoms contain dozens of components, including proteases and phospholipases A

Indexed as

Trypanosoma brucei bruceiAnimalsElapid VenomsEndocytosisHumansMammalsNajaPhospholipases A2Variant Surface Glycoproteins, TrypanosomaElapid VenomsPhospholipases A2Variant Surface Glycoproteins, Trypanosoma

Identifiers

PMID35430620
PMCPMC9013370
OpenAlexW4223971759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.