Evidence map›Paper›PMID 35430325›Full record

Trial reportBehavioural brain research2022

Research outside the laboratory: Longitudinal at-home neurostimulation.

Kevin T Jones, Carson C Smith, Adam Gazzaley, Theodore P Zanto

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Behavioural brain research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kevin T JonesDepartment of Neurology, University of California-San Francisco, San Francisco, CA, USA; Neuroscape, University of California-San Francisco, San Francisco, CA, USA. Electronic address: KevJones22@gmail.com.
Carson C SmithDepartment of Neurology, University of California-San Francisco, San Francisco, CA, USA; Neuroscape, University of California-San Francisco, San Francisco, CA, USA; Department of Integrative Neuroscience, University of Nevada-Reno, Reno, NV, USA.
Adam GazzaleyDepartment of Neurology, University of California-San Francisco, San Francisco, CA, USA; Neuroscape, University of California-San Francisco, San Francisco, CA, USA; Departments of Physiology and Psychiatry, University of California-San Francisco, San Francisco, CA, USA.
Theodore P ZantoDepartment of Neurology, University of California-San Francisco, San Francisco, CA, USA; Neuroscape, University of California-San Francisco, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

Enhancing cognitive control in amnestic mild cognitive impairment via non-invasive brain stimulationR21AG062395 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GAZZALEY, ADAM H, ZANTO, THEODORE P · 2018 to 2019
$377k
NIA NIH HHS R21 AG062395
6 · The paper itself

Abstract

The use of noninvasive transcranial electrical stimulation (tES) has rapidly increased over the past two decades. Yet, tES continues to be largely implemented in laboratory and rehabilitation settings, thereby limiting accessibility to the broader population. We have previously demonstrated that transcranial alternating current stimulation (tACS) in the theta (4-7 Hz) band improves cognitive control, such as multitasking, in younger adults following a single tACS session, as well as in older adults following three tACS sessions. Here, the goal was to extend our in-lab results by (1) assessing the feasibility for at-home tACS and (2) evaluating whether five tACS sessions may yield continuing improvements in multitasking ability in young adults. Participants (aged 18 - 34 years) received bilateral prefrontal tACS while engaged in an adaptive multitasking training over five consecutive days in their home settings. Participants were randomly assigned to receive either 20-minutes of theta or delta tACS during daily multitasking training. Prior to and on the day immediately following five days of tACS, we assessed performance on single task, multitask, and sustained attention ability with analyses of variance statistics. 92.1% of participants were able to self-administer tACS at home without researcher assistance. However, we observed that both theta and delta tACS groups exhibited improvements in both single and multitask performance. Compared to previously collected data, five days of theta tACS was comparable to one day of theta tACS. However, theta tACS has continued benefits in older, but not younger adults as evidenced by previous research. Both groups similarly improved in sustained attention. These results demonstrate that laboratory paradigms utilizing neurostimulation can be effectively deployed in a home environment without direct support from research personnel. Moreover, these results suggest that while theta tACS may facilitate multitasking improvements over one session, multiple sessions of theta tACS results in diminishing returns in young adults. Additional research will be required to confirm if delta activity plays an important role in multitasking ability.

Indexed as

Transcranial Direct Current StimulationAgedHumansMotivationYoung AdultCognitive trainingMultitaskingRemote researchTranscranial alternating current stimulation

Identifiers

PMID35430325
PMCPMC9483846
OpenAlexW4223946739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.